Evidence map›Paper›PMID 28193769›Full record

ReviewCold Spring Harbor perspectives in medicine2017

Long Noncoding RNAs: At the Intersection of Cancer and Chromatin Biology.

Adam M Schmitt, Howard Y Chang

Open access · bronzeAbstract readReview
In one paragraph

Review in Cold Spring Harbor perspectives in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 51 papers.

0numbers the graph read from it
0cells of the map it votes in
51citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

51 citing papers in PubMed, 83 citations in OpenAlex.

  1. Article
  2. Long non-coding RNAeLife · 2024
    Article
  3. Article
  4. Article
  5. The c-Src/LIST Positive Feedback Loop Sustains Tumor Progression and Chemoresistance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  6. Article
  7. Plumbing mysterious RNAs in "dark genome" for the conquest of human diseases.Molecular therapy : the journal of the American Society of Gene Therapy · 2023
    Review
  8. Long non-coding RNAJournal of thoracic disease · 2023
    Article
  9. Targeting LncRNAOncology research · 2023
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Designing libraries for pooled CRISPR functional screens of long noncoding RNAs.Mammalian genome : official journal of the International Mammalian Genome Society · 2022
    Review
  16. Article
  17. Article
  18. A long non-coding RNA with important roles in the carcinogenesis.Frontiers in cell and developmental biology · 2022
    Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Adam M SchmittDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10065.
Howard Y ChangCenter for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, California 94305.
Memorial Sloan Kettering Cancer Center · USStanford University · US

Funding

LncRNA mechanisms in cancerR35CA209919 · NCI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2016 to 2022
$6.4M
Wound Response Genes in Cancer ProgressionR01CA118750 · NCI · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2007 to 2016
$2.9M
LncRNA regulation of environmental responseR01ES023168 · NIEHS · STANFORD UNIVERSITY · PI CHANG, HOWARD Y · 2013 to 2016
$2.2M
NCI NIH HHS R01 CA118750NCI NIH HHS R35 CA209919NIEHS NIH HHS R01 ES023168
6 · The paper itself

Abstract

Although only 2% of the genome encodes protein, RNA is transcribed from the majority of the genetic sequence, suggesting a massive degree of cellular functionality is programmed in the noncoding genome. The mammalian genome contains tens of thousands of long noncoding RNAs (lncRNAs), many of which occur at disease-associated loci or are specifically expressed in cancer. Although the vast majority of lncRNAs have no known function, recurring molecular mechanisms for lncRNAs are now being observed in chromatin regulation and cancer pathways and emerging technologies are now providing tools to interrogate lncRNA molecular interactions and determine function of these abundant cellular macromolecules.

Indexed as

AnimalsChromatinGenomeHumansNeoplasmsPhenotypeRNA, Long NoncodingTranscription, GeneticChromatinRNA, Long Noncoding

Identifiers

PMID28193769
PMCPMC5495049
OpenAlexW2589086765

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.