Evidence map›Paper›PMID 28193765›Full record

ArticlePlant physiology2017

A Novel Chemical Inhibitor of ABA Signaling Targets All ABA Receptors.

Yajin Ye, Lijuan Zhou, Xue Liu, Hao Liu, Deqiang Li, Minjie Cao, Haifeng Chen, Lin Xu, Jian-Kang Zhu, Yang Zhao

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Plant physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 85 citations in OpenAlex.

  1. Article
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  12. Plants (Basel, Switzerland) · 2023
    Article
  13. A Potential ABA Analog to Increase Drought Tolerance inInternational journal of molecular sciences · 2023
    Article
  14. Article
  15. Review
  16. Article
  17. Click-to-lead design of a picomolar ABA receptor antagonist with potent activity in vivo.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  18. Review
  19. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Yajin YeInstitute of Plant Physiology and Ecology (Y.-J.Y., L.-J.Z., D.-Q.L., L.X., Y.Z.) and Shanghai Center for Plant Stress Biology (X.L., M.-J.C., J.-K.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.
Lijuan ZhouInstitute of Plant Physiology and Ecology (Y.-J.Y., L.-J.Z., D.-Q.L., L.X., Y.Z.) and Shanghai Center for Plant Stress Biology (X.L., M.-J.C., J.-K.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.ORCID 0000-0003-0107-5648
Xue LiuInstitute of Plant Physiology and Ecology (Y.-J.Y., L.-J.Z., D.-Q.L., L.X., Y.Z.) and Shanghai Center for Plant Stress Biology (X.L., M.-J.C., J.-K.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.
Hao LiuInstitute of Plant Physiology and Ecology (Y.-J.Y., L.-J.Z., D.-Q.L., L.X., Y.Z.) and Shanghai Center for Plant Stress Biology (X.L., M.-J.C., J.-K.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.
Deqiang LiInstitute of Plant Physiology and Ecology (Y.-J.Y., L.-J.Z., D.-Q.L., L.X., Y.Z.) and Shanghai Center for Plant Stress Biology (X.L., M.-J.C., J.-K.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.
Minjie CaoInstitute of Plant Physiology and Ecology (Y.-J.Y., L.-J.Z., D.-Q.L., L.X., Y.Z.) and Shanghai Center for Plant Stress Biology (X.L., M.-J.C., J.-K.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.
Haifeng ChenInstitute of Plant Physiology and Ecology (Y.-J.Y., L.-J.Z., D.-Q.L., L.X., Y.Z.) and Shanghai Center for Plant Stress Biology (X.L., M.-J.C., J.-K.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.
Lin XuInstitute of Plant Physiology and Ecology (Y.-J.Y., L.-J.Z., D.-Q.L., L.X., Y.Z.) and Shanghai Center for Plant Stress Biology (X.L., M.-J.C., J.-K.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China.ORCID 0000-0003-4718-1286
Jian-Kang ZhuInstitute of Plant Physiology and Ecology (Y.-J.Y., L.-J.Z., D.-Q.L., L.X., Y.Z.) and Shanghai Center for Plant Stress Biology (X.L., M.-J.C., J.-K.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China; zhu132@purdue.edu yangzhaotoronto@sina.com.
Yang ZhaoInstitute of Plant Physiology and Ecology (Y.-J.Y., L.-J.Z., D.-Q.L., L.X., Y.Z.) and Shanghai Center for Plant Stress Biology (X.L., M.-J.C., J.-K.Z.), Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China; zhu132@purdue.edu yangzhaotoronto@sina.com.ORCID 0000-0001-8697-5148
Kunming University of Science and Technology · CNChinese Academy of Sciences · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Abscisic acid (ABA), the most important stress-induced phytohormone, regulates seed dormancy, germination, plant senescence, and the abiotic stress response. ABA signaling is repressed by group A type 2C protein phosphatases (PP2Cs), and then ABA binds to its receptor of the ACTIN RESISTANCE1 (PYR1), PYR1-LIKE (PYL), and REGULATORY COMPONENTS OF ABA RECEPTORS (RCAR) family, which, in turn, inhibits PP2Cs and activates downstream ABA signaling. The agonist/antagonist of ABA receptors have the potential to reveal the ABA signaling machinery and to become lead compounds for agrochemicals; however, until now, no broad-spectrum antagonists of ABA receptors blocking all PYR/PYL-PP2C interactions have been identified. Here, using chemical genetics screenings, we identified ABA ANTAGONIST1 (AA1), the first broad-spectrum antagonist of ABA receptors in Arabidopsis (

Indexed as

Abscisic AcidAgrochemicalsAniline CompoundsArabidopsisArabidopsis ProteinsCarrier ProteinsGene Expression Regulation, PlantIntracellular Signaling Peptides and ProteinsMembrane Transport ProteinsMolecular Docking SimulationMolecular StructurePlant Growth RegulatorsProtein BindingProtein Phosphatase 2CReceptors, Cell SurfaceReverse Transcriptase Polymerase Chain Reaction2,6-Bis(4-anilino)-4-(4-N,N-dimethylanilino)thiopyrylium chlorideAbscisic AcidAgrochemicalsAniline CompoundsArabidopsis ProteinsAT4G17870 protein, ArabidopsisCarrier ProteinsIntracellular Signaling Peptides and ProteinsMembrane Transport ProteinsPlant Growth RegulatorsProtein Phosphatase 2CPYL4 protein, ArabidopsisRCAR1 protein, ArabidopsisReceptors, Cell SurfaceThiophenes

Identifiers

PMID28193765
PMCPMC5373061
OpenAlexW2589128353

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.