Evidence map›Paper›PMID 28193650›Full record

ArticleAntimicrobial agents and chemotherapy2017

Interaction of Rifampin and Darunavir-Ritonavir or Darunavir-Cobicistat

Owain Roberts, Saye Khoo, Andrew Owen, Marco Siccardi

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03892161 (Clinical Evaluation of Adjusted Doses of Darunavir/Ritonavir With Rifampicin in HIV-infected Volunteers), which is not on this map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.9field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03892161 phase1terminatednot on this mapstarted 2018, after this paper: background citation

Clinical Evaluation of Adjusted Doses of Darunavir/Ritonavir With Rifampicin in HIV-infected Volunteers

TypeinterventionalSponsorUniversity of Cape TownRan2018 to 2018Enrolled17ConditionsHIV InfectionsArmsDarunavir/ritonavir 800/100 mg tablet, Rifampicin 600mg QD tablet and DTG 50mg BD
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Owain RobertsDepartment of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.
Saye KhooDepartment of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.
Andrew OwenDepartment of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom.
Marco SiccardiDepartment of Molecular and Clinical Pharmacology, Institute of Translational Medicine, University of Liverpool, Liverpool, United Kingdom siccardi@liverpool.ac.uk.
University of Liverpool · GB

Funding

Medical Research Council G0800247
6 · The paper itself

Abstract

Treatment of HIV-infected patients coinfected with

Indexed as

Antirheumatic AgentsAntitubercular AgentsCells, CulturedCobicistatDarunavirDrug InteractionsDrug Therapy, CombinationHepatocytesHIV-1HIV InfectionsHumansMetabolic Clearance RateMycobacterium tuberculosisRifampinRitonavirTuberculosis, PulmonaryAntirheumatic AgentsAntitubercular AgentsCobicistatDarunavirRifampinRitonavirantiretroviral agentscobicistatdarunavirdrug-drug interactionhuman immunodeficiency virusin vitrorifampinritonavir

Identifiers

PMID28193650
PMCPMC5404587
OpenAlexW2589043006

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.