Evidence map›Paper›PMID 28193646›Full record

ArticleAntimicrobial agents and chemotherapy2017

Simplified Reversed Chloroquines To Overcome Malaria Resistance to Quinoline-Based Drugs.

Bornface Gunsaru, Steven J Burgess, Westin Morrill, Jane X Kelly, Shawheen Shomloo, Martin J Smilkstein, Katherine Liebman, David H Peyton

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Nitropyridines in the Synthesis of Bioactive Molecules.Pharmaceuticals (Basel, Switzerland) · 2025
    Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Bornface GunsaruDepartment of Chemistry, Portland State University, Portland, Oregon, USA.
Steven J BurgessDepartment of Chemistry, Portland State University, Portland, Oregon, USA.
Westin MorrillDesignMedix, Inc., Portland, Oregon, USA.
Jane X KellyDepartment of Chemistry, Portland State University, Portland, Oregon, USA.
Shawheen ShomlooDepartment of Chemistry, Portland State University, Portland, Oregon, USA.
Martin J SmilksteinPortland Veterans Affairs Medical Center, Portland, Oregon, USA.
Katherine LiebmanDepartment of Chemistry, Portland State University, Portland, Oregon, USA.
David H PeytonDepartment of Chemistry, Portland State University, Portland, Oregon, USA peytond@pdx.edu.

Funding

Preclinical development of novel small molecule malaria drugs that overcome drugR42AI094959 · NIAID · DESIGNMEDIX, INC. · PI PEYTON, DAVID H · 2014 to 2016
$3.0M
Designed Antimalarial Agents Overcoming Chloroquine-ResistanceR42AI072923 · NIAID · DESIGNMEDIX, INC. · PI PEYTON, DAVID H · 2009 to 2010
$1.3M
Preclinical development of novel small molecule malaria drugs that overcome drugR41AI094959 · NIAID · DESIGNMEDIX, INC. · PI PEYTON, DAVID H · 2011 to 2012
$600k
Reversed Chloroquines as Antimalarial AgentsR21AI067837 · NIAID · PORTLAND STATE UNIVERSITY · PI PEYTON, DAVID H · 2007 to 2008
$397k
Designed Antimalarial Agents Overcoming Chloroquine-ResistanceR41AI072923 · NIAID · DESIGNMEDIX, INC. · PI PEYTON, DAVID H · 2007 to 2007
$104k
NIAID NIH HHS R21 AI067837NIAID NIH HHS R41 AI072923NIAID NIH HHS R41 AI094959NIAID NIH HHS R42 AI072923NIAID NIH HHS R42 AI094959
6 · The paper itself

Abstract

Building on our earlier work of attaching a chemosensitizer (reversal agent) to a known drug pharmacophore, we have now expanded the structure-activity relationship study to include simplified versions of the chemosensitizer. The change from two aromatic rings in this head group to a single ring does not appear to detrimentally affect the antimalarial activity of the compounds. Data from

Indexed as

AnimalsAntimalarialsChloroquineDrug DiscoveryFemaleHemeHemeproteinsMalaria, FalciparumMicePlasmodium falciparumPlasmodium yoeliiProtein BindingStructure-Activity RelationshipAntimalarialsChloroquineHemeHemeproteinshemozoinaccumulationantimalarialchloroquinedrug developmentdrug discoverydrug resistancehematinhemozoinmalariaPlasmodium falciparumstructure-activity relationship

Identifiers

PMID28193646
PMCPMC5404532

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.