Evidence map›Paper›PMID 28193627›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017

Adoptive Transfer of Invariant NKT Cells as Immunotherapy for Advanced Melanoma: A Phase I Clinical Trial.

Mark A Exley, Phillip Friedlander, Nadia Alatrakchi, Lianne Vriend, Simon Yue, Tetsuro Sasada, Wanyong Zeng, Yo Mizukami, Justice Clark, David Nemer and 8 more

Open access · bronzeAbstract readClinical Trial, Phase I
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
116citing papers in PubMed, 1 pooled it
7.0field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

116 citing papers in PubMed, 1 synthesis or guideline pooled it, 165 citations in OpenAlex.

  1. Pooled it
  2. Trial
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  5. Review
  6. Review
  7. Article
  8. Innate immune cells in chimeric antigen receptor therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2026
    Review
  9. Article
  10. Facts and Hopes of Chimeric Antigen Receptor-Redirected NK T Cells.Clinical cancer research : an official journal of the American Association for Cancer Research · 2025
    Review
  11. Review
  12. Review
  13. Review
  14. Review
  15. Review
  16. Article
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  18. Article
  19. Article
  20. Review

56 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 1 institution in 1 country.

Mark A ExleyHematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. mexley@partners.org sbalk@bidmc.harvard.edu.
Phillip FriedlanderMedical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
Nadia AlatrakchiHematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Lianne VriendHematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Simon YueHematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
Tetsuro SasadaMedical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
Wanyong ZengMedical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
Yo MizukamiMedical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
Justice ClarkHematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts.
David NemerMedical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
Kenneth LeClair
Christine CanningMedical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
Heather DaleyMedical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
Glenn DranoffMedical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
Anita Giobbie-HurderBiostatistics & Computational Biology, Dana Farber Cancer Institute, Harvard School of Public Health, Boston, Massachusetts.
F Stephen HodiMedical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
Jerome RitzMedical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts.
Steven P BalkHematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts. mexley@partners.org sbalk@bidmc.harvard.edu.
University of Manchester · GB

Funding

Tumor and Circulating Markers as Links Between Obesity and Lethal Prostate CanceP50CA090381 · NCI · DANA-FARBER CANCER INSTITUTE · PI LODA, MASSIMO · 2002 to 2017
$36.2M
T CELL NEOGENESIS AFTER STEM CELL TRANSPLANTATIONP01AI029530 · NIAID · DANA-FARBER CANCER INSTITUTE · PI RITZ, JEROME · 1990 to 2003
$4.5M
Regulation of hepatic NKT cells by CDld+ liver cellsR21CA143748 · NCI · BETH ISRAEL DEACONESS MEDICAL CENTER · PI EXLEY, MARK A · 2010 to 2011
$410k
Obesity increased cancer risk by NKT cell depletion (PQ1)R21CA170194 · NCI · BRIGHAM AND WOMEN'S HOSPITAL · PI EXLEY, MARK A · 2012 to 2013
$400k
NCI NIH HHS P50 CA090381NCI NIH HHS R21 CA143748NCI NIH HHS R21 CA170194NIAID NIH HHS P01 AI029530
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ImmunotherapyAdoptive TransferAdultAgedCD3 ComplexCell- and Tissue-Based TherapyFemaleGalactosylceramidesHumansInterferon-gammaInterleukin-10Interleukin-2Interleukin-4Kaplan-Meier EstimateLymphocyte ActivationMalealpha-galactosylceramideCD3 ComplexGalactosylceramidesIL2 protein, humanInterferon-gammaInterleukin-10Interleukin-2Interleukin-4

Identifiers

PMID28193627
PMCPMC5511564
OpenAlexW2588227649

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.