ArticleCirculation. Cardiovascular imaging2017
Apparent Aortic Stiffness in Children With Pulmonary Arterial Hypertension: Existence of Vascular Interdependency?
Article in Circulation. Cardiovascular imaging, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 29 citations in OpenAlex.
- Vascular stiffening in aging females with a hypertension-induced HIF2A gain-of-function mutation.Bioengineering & translational medicine · 2023Article
- Pulmonary Hypertension in Children is Associated With Abnormal Flow Patterns in the Main Pulmonary Artery as Demonstrated by Blood Speckle Tracking.CJC pediatric and congenital heart disease · 2022Article
- Role of cardiovascular magnetic resonance in pediatric pulmonary hypertension-novel concepts and imaging biomarkers.Cardiovascular diagnosis and therapy · 2021Review
- Serum copeptin and NT-proBNP is associated with central aortic stiffness and flow hemodynamics in adolescents with type 1 diabetes: A pilot study.Journal of diabetes and its complications · 2021Article
- Short-Term Effects of Inhaled Nitric Oxide on Right Ventricular Flow Hemodynamics by 4-Dimensional-Flow Magnetic Resonance Imaging in Children With Pulmonary Arterial Hypertension.Journal of the American Heart Association · 2021Article
- Impact of Obesity on Measures of Cardiovascular and Kidney Health in Youth With Type 1 Diabetes as Compared With Youth With Type 2 Diabetes.Diabetes care · 2021Article
- Update on noninvasive imaging of right ventricle dysfunction in pulmonary hypertension.Cardiovascular diagnosis and therapy · 2020Review
- Cardiovascular disease in young People with Type 1 Diabetes: Search for Cardiovascular Biomarkers.Journal of diabetes and its complications · 2020Review
- Proximal pulmonary vascular stiffness as a prognostic factor in children with pulmonary arterial hypertension.European heart journal. Cardiovascular Imaging · 2019Article
- MRI assessment of aortic flow in patients with pulmonary arterial hypertension in response to exercise.BMC medical imaging · 2018Article
- Metformin Improves Insulin Sensitivity and Vascular Health in Youth With Type 1 Diabetes Mellitus.Circulation · 2018Article
- Impact of different coarctation therapies on aortic stiffness: phase-contrast MRI study.The international journal of cardiovascular imaging · 2018Article
- Exercise unmasks distinct pathophysiologic features in heart failure with preserved ejection fraction and pulmonary vascular disease.European heart journal · 2018Article
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9 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundLeft ventricular dysfunction, mediated by ventricular interdependence, has been associated with negative outcomes in children with pulmonary arterial hypertension (PAH). Considering the dilation of the pulmonary arteries as a paramount sign of PAH, we hypothesized that the ascending aorta will present signs of apparent stiffness in children with PAH and that this effect may be because of mechanical interaction with the dilated main pulmonary artery (MPA). METHODS AND
resultsForty-two children with PAH and 26 age- and size-matched controls underwent comprehensive cardiac magnetic resonance evaluation. Assessment of aortic stiffness was evaluated by measuring pulse wave velocity, aortic strain, and distensibility. Children with PAH had significantly increased pulse wave velocity in the ascending aorta (3.4 versus 2.3 m/s for PAH and controls, respectively;
conclusionsPediatric PAH patients have increased apparent ascending aortic stiffness, which was strongly associated with the degree of MPA distension. We speculate that distension of the MPA may play a major role in limiting full aortic expansion during systole, which modulates left ventricular performance and impacts systemic hemodynamics in pediatric PAH.
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