Evidence map›Paper›PMID 28193599›Full record

Trial reportJournal of medical Internet research2017

An Online Intervention Comparing a Very Low-Carbohydrate Ketogenic Diet and Lifestyle Recommendations Versus a Plate Method Diet in Overweight Individuals With Type 2 Diabetes: A Randomized Controlled Trial.

Laura R Saslow, Ashley E Mason, Sarah Kim, Veronica Goldman, Robert Ploutz-Snyder, Hovig Bayandorian, Jennifer Daubenmier, Frederick M Hecht, Judith T Moskowitz

2 registry-linked trialsOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of medical Internet research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 110 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
110citing papers in PubMed, 14 pooled it
19.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01967992 phase2completednot on this map

Examining the Effects of Diet on Health With an Online Program

TypeinterventionalSponsorUniversity of California, San FranciscoRan2013 to 2015Enrolled25ConditionsType 2 DiabetesArmsBehavioral: Low Carbohydrate, Ketogenic Diet, American Diabetes Association Diet, Mindfulness and Positive Affect Skills
NCT06273631 narecruitingnot on this mapstarted 2024, after this paper: background citation

Effect of Changes in Carbohydrate Intake Patterns on Glucose Control in Patients With Type 1 Diabetes

TypeinterventionalSponsorYang TaoRan2024 to 2027Enrolled80ConditionsType 1 Diabetes, Diet Intervention, Glucose ControlArmsdiverse carbohydrate diet, moderate carbohydrate diet
3 · Its place in the literature

Who cites it

110 citing papers in PubMed, 14 syntheses or guidelines pooled it, 274 citations in OpenAlex.

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50 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Laura R SaslowDepartment of Health Behavior and Biological Sciences, School of Nursing, University of Michigan, Ann Arbor, MI, United States.ORCID 0000-0003-3991-3205
Ashley E MasonOsher Center for Integrative Medicine, School of Medicine, University of California, San Francisco, San Francisco, CA, United States.ORCID 0000-0002-8744-0185
Sarah KimSchool of Medicine, University of California, San Francisco, San Francisco, CA, United States.ORCID 0000-0002-3599-5509
Veronica GoldmanOsher Center for Integrative Medicine, School of Medicine, University of California, San Francisco, San Francisco, CA, United States.ORCID 0000-0001-9402-0800
Robert Ploutz-SnyderApplied Biostatistics Laboratory, School of Nursing, University of Michigan, Ann Arbor, MI, United States.ORCID 0000-0002-8503-2073
Hovig BayandorianUniversity of California, Berkeley, Berkeley, CA, United States.ORCID 0000-0003-4596-0323
Jennifer DaubenmierInstitute of Holistic Health, Department of Health Education, San Francisco State University, San Francisco, CA, United States.ORCID 0000-0001-5678-4068
Frederick M HechtOsher Center for Integrative Medicine, School of Medicine, University of California, San Francisco, San Francisco, CA, United States.ORCID 0000-0002-5782-1171
Judith T MoskowitzFeinberg School of Medicine, Northwestern University, Chicago, IL, United States.ORCID 0000-0002-1399-3318
University of California, San Francisco · USUniversity of Michigan · USNorthwestern University · USSan Francisco State University · USUniversity of California, Berkeley · US

Funding

Research BaseP30DK092926 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MARY ELLEN MICHELE HEISLER, ADESUWA B OLOMU · 2011 to 2026
$10.0M
Training Researchers in Clinical Integrative Medicine (TRIM) - NOSI supplementT32AT003997 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI SHELLEY R ADLER, MARIA T CHAO · 2007 to 2026
$6.6M
Mentoring and Research in Integrative MedicineK24AT007827 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI HECHT, FREDERICK M · 2013 to 2022
$1.8M
An experimental medicine approach toward the identification of a compulsive overeating phenotype in obesityK23HL133442 · NHLBI · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MASON, ASHLEY E. · 2016 to 2020
$1.1M
Optimization of a Multicomponent Diet Intervention in Type 2 DiabetesK01DK107456 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI SASLOW, LAURA · 2016 to 2020
$777k
Positive Affect Regulation for HIV Prevention in People with Mood DisordersK24MH093225 · NIMH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MOSKOWITZ, JUDITH T. · 2011 to 2015
$713k
NCCIH NIH HHS K24 AT007827NCCIH NIH HHS T32 AT003997NHLBI NIH HHS K23 HL133442NIDDK NIH HHS K01 DK107456NIDDK NIH HHS P30 DK092926NIMH NIH HHS K24 MH093225
6 · The paper itself

Abstract

backgroundType 2 diabetes is a prevalent, chronic disease for which diet is an integral aspect of treatment. In our previous trial, we found that recommendations to follow a very low-carbohydrate ketogenic diet and to change lifestyle factors (physical activity, sleep, positive affect, mindfulness) helped overweight people with type 2 diabetes or prediabetes improve glycemic control and lose weight. This was an in-person intervention, which could be a barrier for people without the time, flexibility, transportation, social support, and/or financial resources to attend.

objectiveThe aim was to determine whether an online intervention based on our previous recommendations (an ad libitum very low-carbohydrate ketogenic diet with lifestyle factors; "intervention") or an online diet program based on the American Diabetes Associations' "Create Your Plate" diet ("control") would improve glycemic control and other health outcomes among overweight individuals with type 2 diabetes.

methodsIn this pilot feasibility study, we randomized overweight adults (body mass index ≥25) with type 2 diabetes (glycated hemoglobin [HbA

resultsAt 32 weeks, participants in the intervention group reduced their HbA

conclusionsIndividuals with type 2 diabetes improved their glycemic control and lost more weight after being randomized to a very low-carbohydrate ketogenic diet and lifestyle online program rather than a conventional, low-fat diabetes diet online program. Thus, the online delivery of these very low-carbohydrate ketogenic diet and lifestyle recommendations may allow them to have a wider reach in the successful self-management of type 2 diabetes.

trial registrationClinicalTrials.gov NCT01967992; https://clinicaltrials.gov/ct2/show/NCT01967992 (Archived by WebCite at http://www.webcitation.org/6o0fI9Mkq).

Indexed as

Healthy LifestyleInternetDiabetes Mellitus, Type 2Diet, KetogenicFeasibility StudiesFemaleGlycated HemoglobinHumansLife StyleMaleMiddle AgedPilot ProjectsSelf CareGlycated HemoglobindieteHealthtype 2 diabetes mellitusweight loss

Identifiers

PMID28193599
PMCPMC5329646
OpenAlexW2587931644

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.