Evidence map›Paper›PMID 28193517›Full record

ReviewGastroenterology2017

Obesity Energetics: Body Weight Regulation and the Effects of Diet Composition.

Kevin D Hall, Juen Guo

Registry-linked trialOpen access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07083947 (A Randomized, Double-blind, Placebo-controlled Clinical Study to Evaluate the Effect of Herbal Compositions CL19183 and CL24212 on Body Weight, Body Composition and Metabolic Health in Overweight Subjects), which is not on this map. Cited by 182 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
182citing papers in PubMed, 11 pooled it
19.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07083947 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

A Randomized, Double-blind, Placebo-controlled Clinical Study to Evaluate the Effect of Herbal Compositions CL19183 and CL24212 on Body Weight, Body Composition and Metabolic Health in Overweight Subjects

TypeinterventionalSponsorApexCPG LLCRan2025 to 2026Enrolled150ConditionsHealthy ParticipantsArmsCL19183, CL24212, Placebo
3 · Its place in the literature

Who cites it

182 citing papers in PubMed, 11 syntheses or guidelines pooled it, 340 citations in OpenAlex.

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122 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Kevin D HallNational Institute of Diabetes & Digestive & Kidney Diseases, Bethesda, Maryland. Electronic address: kevinh@niddk.nih.gov.
Juen GuoNational Institute of Diabetes & Digestive & Kidney Diseases, Bethesda, Maryland.
National Institute of Diabetes and Digestive and Kidney Diseases · US

Funding

Modeling interactions of diet, exercise, metabolism, and weight change in humansZIADK013037 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI DARCEY, VALERIE · 2009 to 2025
$10.8M
Computational modeling of human metabolism, body weight and compositionZIADK013036 · NIDDK · NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES · PI HALL, KEVIN · 2009 to 2024
$3.6M
Intramural NIH HHS ZIA DK013036Intramural NIH HHS ZIA DK013037
6 · The paper itself

Abstract

Weight changes are accompanied by imbalances between calorie intake and expenditure. This fact is often misinterpreted to suggest that obesity is caused by gluttony and sloth and can be treated by simply advising people to eat less and move more. Rather various components of energy balance are dynamically interrelated and weight loss is resisted by counterbalancing physiological processes. While low-carbohydrate diets have been suggested to partially subvert these processes by increasing energy expenditure and promoting fat loss, our meta-analysis of 32 controlled feeding studies with isocaloric substitution of carbohydrate for fat found that both energy expenditure (26 kcal/d; P <.0001) and fat loss (16 g/d; P <.0001) were greater with lower fat diets. We review the components of energy balance and the mechanisms acting to resist weight loss in the context of static, settling point, and set-point models of body weight regulation, with the set-point model being most commensurate with current data.

Indexed as

Body Weight MaintenanceEnergy IntakeEnergy MetabolismDietExerciseFeedback, PhysiologicalHumansModels, BiologicalObesityRestThermogenesisWeight LossBody Weight RegulationEnergy ExpenditureEnergy IntakeMacronutrients

Identifiers

PMID28193517
PMCPMC5568065
OpenAlexW2586756410

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.