Evidence map›Paper›PMID 28193252›Full record

ReviewParasites & vectors2017

Proteases of haematophagous arthropod vectors are involved in blood-feeding, yolk formation and immunity - a review.

Paula Beatriz Santiago, Carla Nunes de Araújo, Flávia Nader Motta, Yanna Reis Praça, Sébastien Charneau, Izabela M Dourado Bastos, Jaime M Santana

Open access · goldAbstract readReview
In one paragraph

Review in Parasites & vectors, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 1 pooled it
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. ThebioRxiv : the preprint server for biology · 2026
    Article
  6. Article
  7. Article
  8. Anti-IL-4, Anti-IL-17, and Anti-IFN-Gamma Activity in the Saliva ofInternational journal of molecular sciences · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. The biotechnological potential of proteases from hematophagous arthropod vectors.Frontiers in cellular and infection microbiology · 2023
    Article
  15. Review
  16. Functional Role ofInsects · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Paula Beatriz SantiagoLaboratório de Interação Patógeno-Hospedeiro, Departamento de Biologia Celular, Instituto de Ciências Biológicas, Universidade de Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, 70910-900, Brasília, DF, Brazil.
Carla Nunes de AraújoLaboratório de Interação Patógeno-Hospedeiro, Departamento de Biologia Celular, Instituto de Ciências Biológicas, Universidade de Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, 70910-900, Brasília, DF, Brazil.
Flávia Nader MottaLaboratório de Interação Patógeno-Hospedeiro, Departamento de Biologia Celular, Instituto de Ciências Biológicas, Universidade de Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, 70910-900, Brasília, DF, Brazil.
Yanna Reis PraçaLaboratório de Interação Patógeno-Hospedeiro, Departamento de Biologia Celular, Instituto de Ciências Biológicas, Universidade de Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, 70910-900, Brasília, DF, Brazil.
Sébastien CharneauLaboratório de Bioquímica e Química de Proteínas, Departamento de Biologia Celular, Instituto de Ciências Biológicas, Universidade de Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, 70910-900, Brasília, DF, Brazil.
Izabela M Dourado BastosLaboratório de Interação Patógeno-Hospedeiro, Departamento de Biologia Celular, Instituto de Ciências Biológicas, Universidade de Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, 70910-900, Brasília, DF, Brazil.
Jaime M SantanaLaboratório de Interação Patógeno-Hospedeiro, Departamento de Biologia Celular, Instituto de Ciências Biológicas, Universidade de Brasília, Campus Universitário Darcy Ribeiro, Asa Norte, 70910-900, Brasília, DF, Brazil. jsantana@unb.br.
Universidade de Brasília · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ticks, triatomines, mosquitoes and sand flies comprise a large number of haematophagous arthropods considered vectors of human infectious diseases. While consuming blood to obtain the nutrients necessary to carry on life functions, these insects can transmit pathogenic microorganisms to the vertebrate host. Among the molecules related to the blood-feeding habit, proteases play an essential role. In this review, we provide a panorama of proteases from arthropod vectors involved in haematophagy, in digestion, in egg development and in immunity. As these molecules act in central biological processes, proteases from haematophagous vectors of infectious diseases may influence vector competence to transmit pathogens to their prey, and thus could be valuable targets for vectorial control.

Indexed as

Feeding BehaviorAgedAnimalsArthropod ProteinsArthropod VectorsEgg YolkHumansPeptide HydrolasesArthropod ProteinsPeptide HydrolasesDigestionHaematophagyImmunityMosquitoesProteasesTicksTriatominesYolk formation

Identifiers

PMID28193252
PMCPMC5307778
OpenAlexW2588632362

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.