ArticleBMC endocrine disorders2017
Corticomedullary mixed tumour resembling a small adrenal gland-involvement of cancer stem cells: case report.
Article in BMC endocrine disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.
- Adrenal mixed corticomedullary tumors: report of a case with molecular characterization and systematic review.Virchows Archiv : an international journal of pathology · 2026Pooled it
- Unilateral mixed corticomedullary tumor of the adrenal gland with a synchronous contralateral pheochromocytoma: A case report and literature review.Urology case reports · 2026Article
- Mixed Corticomedullary Tumor of the Adrenal Gland: A Case Report and Literature Review.Medicina (Kaunas, Lithuania) · 2023Review
- Current Understanding of "Mixed Corticomedullary Adrenal Tumor" and an Insight into Genomic Profiling.Clinics and practice · 2022Review
- Mixed corticomedullary tumor of the adrenal gland.Frontiers in endocrinology · 2022Review
- Mixed Corticomedullary Tumor Accompanied by Unilateral Aldosterone-Producing Adrenocortical Micronodules: a Case Report.Journal of the Endocrine Society · 2021Article
- Adrenal Corticomedullary Mixed Tumor Associated With theJournal of the Endocrine Society · 2020Article
- From ACTH-Dependent to ACTH-Independent Cushing's Syndrome from a Malignant Mixed Corticomedullary Adrenal Tumor: Potential Role of Embryonic Stem Cells.Case reports in endocrinology · 2020Article
- Synchronous ipsilateral adrenal cortical adenoma and ganglioneuroma: A case report.Indian journal of urology : IJU : journal of the Urological Society of IndiaArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundAdrenal corticomedullary mixed tumours are very rare. Its mechanism is rarely reported. Here we report the first case of a corticomedullary mixed tumour resembling a "small adrenal gland" with distinct arrangement of the cortical and medullary layers. We further hypothesize regarding the tumorigenic mechanism of this tumour. CASE PRESENTATION: A 58-year man had been diagnosed with diabetes and hypertension for 3 years. His 24-h urine vanillylmandelic acid (VMA) levels were slightly elevated. An abnormal circadian cortisol rhythm was noted, and his cortisol levels were not suppressed by dexamethasone. Abdominal computed tomography (CT) revealed a right adrenal gland lesion (diameter, 30 × 38 mm), while an enhanced CT showed enhancement and hypervascularization. The tumour was positive for adrenocorticotropic hormone, chromogranin A (CGA), and steroidogenic factor-1 (SF-1) on the tumour surface. Acetaldehyde dehydrogenase 1(ALDH1), CD44, CD133, Nestin, Nerve growth factor receptor (NGFR), and Sex determining region y-box 9(SOX9) staining were positive. Although administration of medications for diabetes and hypertension was stopped until surgery was performed, the blood sugar level and blood pressure were maintained after surgery.
conclusionsThis is the first report about a possible mechanism by which cancer stem cells induce adrenal corticomedullary tumours.
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