ArticleJournal of child neurology2017
Characterization of Death in Neonatal Encephalopathy in the Hypothermia Era.
Article in Journal of child neurology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05733975 (Decision Making Support for Parents and Caregivers), which is not on this map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Decision Making Support for Parents and Caregivers
Who cites it
20 citing papers in PubMed, 31 citations in OpenAlex.
- Should Australia Adopt a Groningen Like Protocol?Journal of bioethical inquiry · 2026Article
- Automated EEG Background Analysis and 2-Year Outcomes in Neonatal Hypoxic-Ischemic Encephalopathy.JAMA network open · 2025Article
- Enhancing shared decision-making for infants in the intensive care unit: lessons from parents.Pediatric research · 2025Article
- Feasibility of an Intervention to Support Shared Decision-Making for Critically Ill Infants.The Journal of pediatrics · 2025Article
- Predictors of Death or Severe Impairment in Neonates With Hypoxic-Ischemic Encephalopathy.JAMA network open · 2024Article
- Pediatric Perspectives on Palliative Care in the Neurocritical Care Unit.Neurocritical care · 2024Review
- Treating Seizures and Improving Newborn Outcomes for Infants with Hypoxic-Ischemic Encephalopathy.Clinics in perinatology · 2024Review
- Beyond Legal Boundaries: Public and Clinician Perspectives on Treatment Withdrawal in Infants With Poor Neurological Prognosis.Journal of Korean medical science · 2024Article
- Seminars in Fetal & neonatal medicine: Palliative and end of life care in the NICU.Seminars in fetal & neonatal medicine · 2023Review
- Review
- The ALIGN Framework: A Parent-Informed Approach to Prognostic Communication for Infants With Neurologic Conditions.Neurology · 2023Article
- Neonatal neuropalliative care.Handbook of clinical neurology · 2023Review
- Characterizing the Language Used to Discuss Death in Family Meetings for Critically Ill Infants.JAMA network open · 2022Article
- Prognostic Discussion for Infants with Neurologic Conditions: Qualitative Analysis of Family Conferences.Annals of neurology · 2022Article
- Decisional Satisfaction, Regret, and Conflict Among Parents of Infants with Neurologic Conditions.The Journal of pediatrics · 2022Article
- Neuropalliative Care for Neonates.Journal of child neurology · 2021Review
- Prognostic value of neonatal EEG following therapeutic hypothermia in survivors of hypoxic-ischemic encephalopathy.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2021Article
- The application of magnetic resonance imaging and diffusion-weighted imaging in the diagnosis of hypoxic-ischemic encephalopathy and kernicterus in premature infants.Translational pediatrics · 2021Article
- Characterization of Death in Infants With Neonatal Seizures.Pediatric neurology · 2020Observational
- Therapeutic Hypothermia: How Can We Optimize This Therapy to Further Improve Outcomes?Clinics in perinatology · 2018Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
This study aimed to characterize the circumstances of death in encephalopathic neonates treated with therapeutic hypothermia. Patients who died after or during treatment with therapeutic hypothermia between 2007-2014 were identified. Patient circumstance of death was characterized using an established paradigm. Thirty-one of 229 patients died (14%) at a median of 3 days of life. Most who died were severely encephalopathic on examination (90%) and had severely abnormal electroencephalographic (EEG) findings (87%). All those who had magnetic resonance images (n = 13) had evidence of moderate-severe brain injury; 6 had near-total brain injury. Cooling was discontinued prematurely in 61% of patients. Most patients (90%) were physiologically stable at the time of death; 81% died following elective extubation for quality of life considerations. Three patients (10%) died following withholding or removal of artificial hydration and nutrition. Characterization of death in additional cohorts is needed to identify differences in decision making practices over time and between centers.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.