ArticleBiomedicine & pharmacotherapy = Biomedecine & pharmacotherapie2017
Effect of hyperglycemia on brain and liver
Article in Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
33 citing papers in PubMed, 3 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Relationships Between Brain Glucose Metabolism Patterns and Impaired Glycemic Status: A Systematic Review of FDG-PET Studies With a Focus on Alzheimer's Disease.Human brain mapping · 2025Pooled it
- Effect of blood glucose level on standardized uptake value (SUV) inEuropean journal of nuclear medicine and molecular imaging · 2019Pooled it
- Effects of blood glucose level on 18F-FDG uptake for PET/CT in normal organs: A systematic review.PloS one · 2018Pooled it
- A ketogenic diet reduces hepatic alcohol metabolism and alcohol consumption in rats.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Article
- The brain-white adipose tissue axis may play a crucial role in diabetes mellitus: a metabolic network analysis using total-body PET/CT imaging.European journal of nuclear medicine and molecular imaging · 2025Article
- Measurement of brain glucose metabolism in obesity and diabetes.Diabetologia · 2025Review
- Development of a Diagnostic Prediction Model for Post-Stroke Cognitive Impairment in Acute Large Vessel Occlusion Stroke Using Multimodal MRI and PET/CT: A Study Protocol.Brain and behavior · 2025Article
- Regional brain glucose uptake following gastric bypass surgery during normo- and hypoglycemic clamp: a pilot FDG-PET study.Endocrine · 2025Article
- Exploratory Dual PET imaging of [Bioorganic & medicinal chemistry letters · 2024Article
- Cerebellum/liver index on baseline 18F-FDG PET/CT to improve prognostication in post-transplant lymphoproliferative disorders: a multicenter retrospective study.EJNMMI research · 2024Article
- Comparison between an SGLT2 inhibitor and insulin in tumor-to-tissue contrasts inScientific reports · 2023Article
- Hyperpolarized [1-Yonsei medical journal · 2023Article
- Predictors of infectious foci on FDG PET/CT in Staphylococcus aureus bacteremia.Scientific reports · 2023Article
- Identification ofNutrients · 2023Article
- Prospective Evaluation of Quantitative F-18-FDG-PET/CT for Pre-Operative Thoracic Lymph Node Staging in Patients with Lung Cancer as a Target for Computer-Aided Diagnosis.Diagnostics (Basel, Switzerland) · 2023Article
- Impact of Reduced Image Noise on Deauville Scores in Patients with Lymphoma Scanned on a Long-Axial Field-of-View PET/CT-Scanner.Diagnostics (Basel, Switzerland) · 2023Article
- Reproducibility of [18F]FDG PET/CT liver SUV as reference or normalisation factor.European journal of nuclear medicine and molecular imaging · 2023Article
- Regional differences in the reduction in cerebral FDG uptake induced by the ketogenic diet.European journal of hybrid imaging · 2022Article
- Evaluation ofCanadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2022Article
- Intrapatient variability of 18F-FDG uptake in normal tissues.Journal of clinical imaging science · 2022Article
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
purposeBlood glucose is routinely measured prior to
methods436 FDG PET/CT consecutive studies performed for oncology staging in 229 patients (226 male) at the Ann Arbor Veterans Administration Healthcare System were reviewed. All patients had blood glucose measured (112.4±34.1mg/dL) prior to injection of 466.2±51.8MBq (12.6±1.4mCi) of FDG. SUV measurements of brain, aortic arch blood-pool, liver, and spleen were obtained at 64.5±10.2min' post-injection.
resultsWe found a negative inverse relationship of brain SUV with increasing plasma glucose, levels for both absolute and normalized (either to blood-pool or liver) values. Higher blood glucose levels had a mild effect upon liver and blood-pool SUV. By contrast, spleen SUV was independent of blood glucose, but demonstrated the greatest variability (deviation on linear regression). In contrast to other tissues, liver and spleen SUV normalized to blood-pool SUV were not dependent upon blood glucose levels.
conclusionThe effects of hyperglycemia upon FDG uptake in brain and liver, over a range of blood glucose values generally considered acceptable for clinical PET imaging, may have measurable effects on semi-quantitative image analysis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.