ArticleJournal of affective disorders2017
Neurophysiological correlates of suicidal ideation in major depressive disorder: Hyperarousal during sleep.
Article in Journal of affective disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 38 papers.
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Who cites it
38 citing papers in PubMed.
- Functional changes in sleep-related arousal after ketamine administration in individuals with treatment-resistant depression.Translational psychiatry · 2024Trial
- Association between irritability and suicidal ideation in three clinical trials of adults with major depressive disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2020Trial
- The selective orexin-2 antagonist seltorexant (JNJ-42847922/MIN-202) shows antidepressant and sleep-promoting effects in patients with major depressive disorder.Translational psychiatry · 2019Trial
- Temporal dynamic brain-heart interaction alterations associated with suicidal ideation in major depressive disorder.BMC psychiatry · 2026Article
- EEG complexity analysis using enhanced entropy features for depression detection and severity classification.Journal of neuroengineering and rehabilitation · 2026Article
- Neurophysiological features in women with antenatal depressive symptoms: a resting-state quantitative electroencephalography study.European archives of psychiatry and clinical neuroscience · 2026Article
- Uncovering oscillatory dysregulation associated with suicide risk in major depressive disorder: a narrative review.Translational psychiatry · 2026Review
- Understanding Latine disparities in nocturnal wakefulness as a suicide risk factor.Sleep epidemiology · 2025Article
- Review: Suicide and its relationship to aggression and impulsivity.Cognitive, affective & behavioral neuroscience · 2025Review
- Alpha oscillatory dysregulation: mapping EEG oscillatory in suicidal depression.Frontiers in human neuroscience · 2025Article
- Implications of Aperiodic and Periodic EEG Components in Classification of Major Depressive Disorder from Source and Electrode Perspectives.Sensors (Basel, Switzerland) · 2024Article
- [Insomniac symptoms and suicidality-link and management].Neuropsychiatrie : Klinik, Diagnostik, Therapie und Rehabilitation : Organ der Gesellschaft Osterreichischer Nervenarzte und Psychiater · 2024Review
- From trenches to technology: a narrative review of sleep medicine in the military.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2024Review
- Insomnia-related brain functional correlates in first-episode drug-naïve major depressive disorder revealed by resting-state fMRI.Frontiers in neuroscience · 2024Article
- Alpha oscillation mediates the interaction between suicide risk and symptom severity in Major Depressive Disorder.Frontiers in neuroscience · 2024Article
- A Bibliometric Analysis of the WoSCC Literature on the Use of Selective Serotonin Reuptake Inhibitors as Antidepressants.Drug design, development and therapy · 2024Article
- Sleep disturbance and suicidality in psychiatrically hospitalized adolescents: The role of specific emotion regulation domains.Journal of clinical psychology · 2023Article
- A resting state EEG study on depressed persons with suicidal ideation.IBRO neuroscience reports · 2023Article
- The mediating role of sleep quality on the relationship between internet gaming disorder and perceived stress and suicidal behaviour among Indian medical students.General psychiatry · 2023Article
- Self-reported sleep quality and mental health mediate the relationship between chronic diseases and suicidal ideation among Chinese medical students.Scientific reports · 2022Article
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Authors and funding
10 authors.
Funding
Abstract
backgroundSuicide is a major public health concern, and a barrier to reducing the suicide rate is the lack of objective predictors of risk. The present study considers whether quantitative sleep electroencephalography (EEG) may be a neurobiological correlate of suicidal ideation.
methodsParticipants included 84 (45 female, mean age=26.6) adults diagnosed with major depressive disorder (MDD). The item that measures thoughts of death or suicide on the Quick Inventory of Depressive Symptomatology (QIDS) was used to classify 47 participants as low suicidal ideation (24 females, mean age=26.1) and 37 as high suicidal ideation (21 females, mean age=27.3). Data were obtained from archival samples collected at the University of Michigan and University of Texas Southwestern Medical Center between 2004 and 2012. Sleep EEG was quantified using power spectral analysis, and focused on alpha, beta, and delta frequencies.
resultsResults indicated that participants with high compared to low suicidal ideation experienced 1) increased fast frequency activity, 2) decreased delta activity, and 3) increased alpha-delta sleep after adjusting for age, sex, depression, and insomnia symptoms. LIMITATIONS: Limitations include the exclusion of imminent suicidal intent, a single suicidal ideation item, and cross-sectional archival data.
conclusionsThis is one of the first studies to provide preliminary support that electrophysiological brain activity during sleep is associated with increased suicidal ideation in MDD, and may point toward central nervous system (CNS) hyperarousal during sleep as a neurobiological correlate of suicidal ideation.
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