ArticlePloS one2017
In vivo functional neurochemistry of human cortical cholinergic function during visuospatial attention.
Article in PloS one, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 2 of them syntheses that pooled it.
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Who cites it
13 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Variability and Magnitude of Choline Levels Across the Psychosis Spectrum: A Meta-analysis.Schizophrenia bulletin · 2026Pooled it
- Mitochondrial dysfunction, oxidative stress, neuroinflammation, and metabolic alterations in the progression of Alzheimer's disease: A meta-analysis of in vivo magnetic resonance spectroscopy studies.Ageing research reviews · 2021Pooled it
- How can I measure brain acetylcholine levels in vivo? Advantages and caveats of commonly used approaches.Journal of neurochemistry · 2023Review
- Event-related functional magnetic resonance spectroscopy.NeuroImage · 2023Review
- Microstructural imaging and transcriptomics of the basal forebrain in first-episode psychosis.Translational psychiatry · 2022Article
- Dissociable roles for the striatal cholinergic system in different flexibility contexts.IBRO neuroscience reports · 2022Article
- Bilingualism is a long-term cognitively challenging experience that modulates metabolite concentrations in the healthy brain.Scientific reports · 2021Article
- Frontal lobe metabolic alterations characterizing Parkinson's disease cognitive impairment.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2021Article
- Neurochemistry of Visual Attention.Frontiers in neuroscience · 2021Review
- Non-invasive characterization of amyotrophic lateral sclerosis in a hTDP-43NeuroImage. Clinical · 2020Article
- Regional Striatal Cholinergic Involvement in Human Behavioral Flexibility.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Functional Magnetic Resonance Spectroscopy: The "New" MRS for Cognitive Neuroscience and Psychiatry Research.Frontiers in psychiatry · 2018Review
- Recent advances in treatment of spatial neglect: networks and neuropsychology.Expert review of neurotherapeuticsReview
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cortical acetylcholine is involved in key cognitive processes such as visuospatial attention. Dysfunction in the cholinergic system has been described in a number of neuropsychiatric disorders. Levels of brain acetylcholine can be pharmacologically manipulated, but it is not possible to directly measure it in vivo in humans. However, key parts of its biochemical cascade in neural tissue, such as choline, can be measured using magnetic resonance spectroscopy (MRS). There is evidence that levels of choline may be an indirect but proportional measure of acetylcholine availability in brain tissue. In this study, we measured relative choline levels in the parietal cortex using functional (event-related) MRS (fMRS) during performance of a visuospatial attention task, with a modelling approach verified using simulated data. We describe a task-driven interaction effect on choline concentration, specifically driven by contralateral attention shifts. Our results suggest that choline MRS has the potential to serve as a proxy of brain acetylcholine function in humans.
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