Observational studyPLoS neglected tropical diseases2017
Multibacillary leprosy by population groups in Brazil: Lessons from an observational study.
Observational study in PLoS neglected tropical diseases, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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Who cites it
35 citing papers in PubMed, 139 citations in OpenAlex.
- Relationship between social participation and stigma in people affected by leprosy: A cross-sectional study in northeastern Brazil.Belitung nursing journal · 2026Article
- Associated Factors of Mycobacterium Leprae Infection among People with Leprosy in Kwale County.PLoS neglected tropical diseases · 2025Article
- Unveiling inflammatory biomarkers in multibacillary leprosy: the role of lymphocyte-platelet ratio in predicting leprosy reactions.Archives of dermatological research · 2024Article
- Use of an inertial sensor and a force platform to assess static balance in participants affected by multibacillary leprosy.PLoS neglected tropical diseases · 2024Observational
- Global patterns of syphilis, gonococcal infection, typhoid fever, paratyphoid fever, diphtheria, pertussis, tetanus, and leprosy from 1990 to 2021: findings from the Global Burden of Disease Study 2021.Infectious diseases of poverty · 2024Article
- Genetic diversity of Mycobacterium leprae: Need to move towards genome-wide approaches.The Indian journal of medical research · 2024Review
- The Many Hosts of Mycobacteria 9 (MHM9): A conference report.Tuberculosis (Edinburgh, Scotland) · 2023Article
- Endoscopic Cubital Tunnel Release in Leprosy Neuritis of the Ulnar Nerve.Revista brasileira de ortopedia · 2023Article
- Clinical-epidemiological characteristics and temporal trend of new cases of grade 2 disability leprosy in the state of Maranhão, Brazil, 2011- 2020.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2023Article
- Article
- Serum Levels of Ficolin-3 and Mannose-Binding Lectin in Patients with Leprosy and Their Family Contacts in a Hyperendemic Region in Northeastern Brazil.Tropical medicine and infectious disease · 2022Article
- Assessment of neuropathic pain in leprosy patients with relapse or treatment failure by infrared thermography: A cross-sectional study.PLoS neglected tropical diseases · 2021Article
- Estimating underreporting of leprosy in Brazil using a Bayesian approach.PLoS neglected tropical diseases · 2021Article
- Leprosy Screening Based on Artificial Intelligence: Development of a Cross-Platform App.JMIR mHealth and uHealth · 2021Article
- Physical disabilities caused by leprosy in 100 million cohort in Brazil.BMC infectious diseases · 2021Article
- Increased oxidative stress in elderly leprosy patients is related to age but not to bacillary load.PLoS neglected tropical diseases · 2021Article
- Leprosy incidence and risk estimates in a 33-year contact cohort of leprosy patients.Scientific reports · 2021Article
- Status and forecast of leprosy in the still endemic province of Formosa in northern Argentina.PLoS neglected tropical diseases · 2021Article
- Presence of Senescent and Memory CD8+ Leukocytes as Immunocenescence Markers in Skin Lesions of Elderly Leprosy Patients.Frontiers in immunology · 2021Article
- Factors Influencing Leprosy Incidence: A Comprehensive Analysis of Observations in Wenshan of China, Nepal, and Other Global Epidemic Areas.Frontiers in public health · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundLeprosy remains an important public health problem in Brazil where 28,761 new cases were diagnosed in 2015, the second highest number of new cases detected globally. The disease is caused by Mycobacterium leprae, a pathogen spread by patients with multibacillary (MB) leprosy. This study was designed to identify population groups most at risk for MB disease in Brazil, contributing to new ideas for early diagnosis and leprosy control.
methodsA national databank of cases reported in Brazil (2001-2013) was used to evaluate epidemiological characteristics of MB leprosy. Additionally, the databank of a leprosy reference center was used to determine factors associated with higher bacillary loads.
resultsA total of 541,090 cases were analyzed. New case detection rates (NCDRs) increased with age, especially for men with MB leprosy, reaching 44.8 new cases/100,000 population in 65-69 year olds. Males and subjects older than 59 years had twice the odds of MB leprosy than females and younger cases (OR = 2.36, CI95% = 2.33-2.38; OR = 1.99, CI95% = 1.96-2.02, respectively). Bacillary load was higher in male and in patients aged 20-39 and 40-59 years compared to females and other age groups. From 2003 to 2013, there was a progressive reduction in annual NCDRs and an increase in the percentage of MB cases and of elderly patients in Brazil. These data suggest reduction of leprosy transmission in the country.
conclusionPublic health policies for leprosy control in endemic areas in Brazil should include activities especially addressed to men and to the elderly in order to further reduce M. leprae transmission.
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