Evidence map›Paper›PMID 28192414›Full record

ArticleNature chemical biology2017

Selective in vivo metabolic cell-labeling-mediated cancer targeting.

Hua Wang, Ruibo Wang, Kaimin Cai, Hua He, Yang Liu, Jonathan Yen, Zhiyu Wang, Ming Xu, Yiwen Sun, Xin Zhou and 11 more

Open access · greenAbstract read
In one paragraph

Article in Nature chemical biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 136 papers.

0numbers the graph read from it
0cells of the map it votes in
136citing papers in PubMed
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

136 citing papers in PubMed, 369 citations in OpenAlex.

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  14. Aluminum-[EJNMMI radiopharmacy and chemistry · 2025
    Article
  15. Review
  16. Small-molecule control of CAR T cells.Nature reviews. Chemistry · 2025
    Review
  17. Advances in integrating biomaterials with CAR-T cells for enhancing solid tumor therapy.Chinese journal of cancer research = Chung-kuo yen cheng yen chiu · 2025
    Article
  18. bioRxiv : the preprint server for biology · 2025
    Article
  19. Article
  20. Article

76 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 4 institutions in 2 countries.

Hua WangDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Ruibo WangDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.ORCID 0000-0002-8753-7163
Kaimin CaiDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.ORCID 0000-0001-9442-8312
Hua HeJiangsu Key Laboratory for Carbon-Based Functional Materials &Devices, Institute of Functional Nano &Soft Materials (FUNSOM), Soochow University, Jiangsu, China.
Yang LiuDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Jonathan YenDepartment of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Zhiyu WangDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Ming XuDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Yiwen SunDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Xin ZhouDepartment of Chemistry, University of Science and Technology of China, Hefei, Anhui, China.
Qian YinDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Li TangDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Iwona T DobruckiBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Lawrence W DobruckiDepartment of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.ORCID 0000-0002-6807-217X
Eric J ChaneyBeckman Institute for Advanced Science and Technology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Stephen A BoppartDepartment of Bioengineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Timothy M FanDepartment of Veterinary Clinical Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Stéphane LezmiDepartment of Pathobiology at College of Veterinary Medicine, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
Xuesi ChenKey Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Changchun, People's Republic of China.
Lichen YinJiangsu Key Laboratory for Carbon-Based Functional Materials &Devices, Institute of Functional Nano &Soft Materials (FUNSOM), Soochow University, Jiangsu, China.
Jianjun ChengDepartment of Materials Science and Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA.
University of Illinois Urbana-Champaign · USSoochow University · CNChangchun Institute of Applied Chemistry · CNUniversity of Science and Technology of China · CN

Funding

Intraoperative Label-Free Optical Molecular Imaging of Breast Tumor MarginsR01CA166309 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BOPPART, STEPHEN A · 2012 to 2016
$2.5M
Developing Clinically Applicable, Cancer-Targeting Polymeric NanoconjugatesDP2OD007246 · OD · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI CHENG, JIANJUN · 2010 to 2010
$2.4M
Training the Next Generation of Researchers in Cancer Nanotechnology at the NCI MR25CA154015 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI BASHIR, RASHID, NARDULLI, ANN · 2010 to 2014
$1.5M
Cancer Targeting through Drug ConjugatesR21CA198684 · NCI · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN · PI CHENG, JIANJUN · 2017 to 2018
$366k
Howard Hughes Medical InstituteNCI NIH HHS R01 CA166309NCI NIH HHS R21 CA198684NCI NIH HHS R25 CA154015NIH HHS DP2 OD007246
6 · The paper itself

Abstract

Distinguishing cancer cells from normal cells through surface receptors is vital for cancer diagnosis and targeted therapy. Metabolic glycoengineering of unnatural sugars provides a powerful tool to manually introduce chemical receptors onto the cell surface; however, cancer-selective labeling still remains a great challenge. Herein we report the design of sugars that can selectively label cancer cells both in vitro and in vivo. Specifically, we inhibit the cell-labeling activity of tetraacetyl-N-azidoacetylmannosamine (Ac

Indexed as

AnimalsApoptosisBreast NeoplasmsCarbohydratesCell Line, TumorColonic NeoplasmsDose-Response Relationship, DrugDrug DesignDrug Screening Assays, AntitumorFemaleHumansMiceMice, Inbred BALB CMice, NudeMolecular ProbesMolecular StructureCarbohydratesMolecular Probes

Identifiers

PMID28192414
PMCPMC5458775
OpenAlexW2588301364

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.