ArticleNature neuroscience2017
Cadherins mediate cocaine-induced synaptic plasticity and behavioral conditioning.
Article in Nature neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 31 citations in OpenAlex.
- Chronic Desipramine Reverses Deficits in Cell Activity, Norepinephrine Innervation, and Anxiety-Depression Phenotypes in Fluoxetine-Resistant cF1ko Mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Neuromechanobiology: An Expanding Field Driven by the Force of Greater Focus.Advanced healthcare materials · 2021Review
- Immunoelectron Microscopic Characterization of Vasopressin-Producing Neurons in the Hypothalamo-Pituitary Axis of Non-Human Primates by Use of Formaldehyde-Fixed Tissues Stored at -25 °C for Several Years.International journal of molecular sciences · 2021Article
- Regulation of hippocampal excitatory synapses by the Zdhhc5 palmitoyl acyltransferase.Journal of cell science · 2021Article
- Cellular responses and functions of α7 nicotinic acetylcholine receptor activation in the brain: a narrative review.Annals of translational medicine · 2021Review
- Mice with cleavage-resistant N-cadherin exhibit synapse anomaly in the hippocampus and outperformance in spatial learning tasks.Molecular brain · 2021Article
- Mechanistic advances in axon pathfinding.Current opinion in cell biology · 2020Review
- Cocaine-induced release of CXCL10 from pericytes regulates monocyte transmigration into the CNS.The Journal of cell biology · 2019Article
- Approaches and Limitations in the Investigation of Synaptic Transmission and Plasticity.Frontiers in synaptic neuroscience · 2019Article
- Direct imaging of uncoated biological samples enables correlation of super-resolution and electron microscopy data.Scientific reports · 2018Article
- Glutamate Receptor-Mediated Neurotoxicity in a Model of Ethanol Dependence and Withdrawal in Rat Organotypic Hippocampal Slice Cultures.Frontiers in neuroscience · 2018Article
- The Emerging Role of Mechanics in Synapse Formation and Plasticity.Frontiers in cellular neuroscience · 2018Review
- Functional roles of p120ctn family of proteins in central neurons.Seminars in cell & developmental biology · 2017Review
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
Drugs of abuse alter synaptic connections in the reward circuitry of the brain, which leads to long-lasting behavioral changes that underlie addiction. Here we show that cadherin adhesion molecules play a critical role in mediating synaptic plasticity and behavioral changes driven by cocaine. We demonstrate that cadherin is essential for long-term potentiation in the ventral tegmental area and is recruited to the synaptic membranes of excitatory synapses onto dopaminergic neurons following cocaine-mediated behavioral conditioning. Furthermore, we show that stabilization of cadherin at the membrane of these synapses blocks cocaine-induced synaptic plasticity, leading to a reduction in conditioned place preference induced by cocaine. Our findings identify cadherins and associated molecules as targets of interest for understanding pathological plasticity associated with addiction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.