ArticleNature neuroscience2017
Retinal origin of direction selectivity in the superior colliculus.
Article in Nature neuroscience, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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Who cites it
59 citing papers in PubMed, 108 citations in OpenAlex.
- Natural motion statistics unify direction computations.bioRxiv : the preprint server for biology · 2026Article
- A collicular-hypothalamic pathway for social visual awareness.bioRxiv : the preprint server for biology · 2026Article
- Visual Motion Processing in The Tree Shrew Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Connectivity, Computation, and Plasticity of the Early Visual System.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Review
- Differential topographic organization and retinal inheritance of direction and orientation selectivity in the visual thalamus.Nature communications · 2025Article
- Coordination of distinct sources of excitatory inputs enhances motion selectivity in the mouse visual thalamus.Neuron · 2025Article
- On analogies in vertebrate and insect visual systems.Nature reviews. Neuroscience · 2025Review
- Computational evidence for an inverse relationship between retinal and brain complexity.Journal of vision · 2025Article
- Accessing genetically defined cell types in the superior colliculus with transgenic mouse lines.iScience · 2025Article
- Bilateral astrocyte reaction to unilateral insult in the optic projection to the brain.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Experience-dependent plasticity of multiple receptive field properties in lateral geniculate binocular neurons during the critical period.Frontiers in cellular neuroscience · 2025Article
- Genetically defined neuron types underlying visuomotor transformation in the superior colliculus.Nature reviews. Neuroscience · 2024Review
- Development and organization of the retinal orientation selectivity map.Nature communications · 2024Article
- Transformation of Motion Pattern Selectivity from Retina to Superior Colliculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Retinal origin of orientation but not direction selective maps in the superior colliculus.Current biology : CB · 2024Article
- Predation without direction selectivity.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Enhancement and contextual modulation of visuospatial processing by thalamocollicular projections from ventral lateral geniculate nucleus.Nature communications · 2023Article
- Retinal input integration in excitatory and inhibitory neurons in the mouse superior colliculus in vivo.eLife · 2023Article
- Pathway-specific inputs to the superior colliculus support flexible responses to visual threat.Science advances · 2023Article
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Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Detecting visual features in the environment, such as motion direction, is crucial for survival. The circuit mechanisms that give rise to direction selectivity in a major visual center, the superior colliculus (SC), are entirely unknown. We optogenetically isolate the retinal inputs that individual direction-selective SC neurons receive and find that they are already selective as a result of precisely converging inputs from similarly tuned retinal ganglion cells. The direction-selective retinal input is linearly amplified by intracollicular circuits without changing its preferred direction or level of selectivity. Finally, using two-photon calcium imaging, we show that SC direction selectivity is dramatically reduced in transgenic mice that have decreased retinal selectivity. Together, our studies demonstrate a retinal origin of direction selectivity in the SC and reveal a central visual deficit as a consequence of altered feature selectivity in the retina.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.