Evidence map›Paper›PMID 28192161›Full record

ArticleCellular signalling2017

Enzymatic cleavage of myoferlin releases a dual C2-domain module linked to ERK signalling.

Ann-Katrin Piper, Samuel E Ross, Gregory M Redpath, Frances A Lemckert, Natalie Woolger, Adam Bournazos, Peter A Greer, Roger B Sutton, Sandra T Cooper

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cellular signalling, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Otoferlin as a multirole CaFrontiers in cellular neuroscience · 2023
    Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Truncating Variant inFrontiers in genetics · 2019
    Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 3 countries.

Ann-Katrin PiperInstitute for Neuroscience and Muscle Research, Children's Hospital at Westmead, Sydney, NSW 2145, Australia; Discipline of Child and Adolescent Health, Faculty of Medicine, University of Sydney, Sydney, Australia.
Samuel E RossInstitute for Neuroscience and Muscle Research, Children's Hospital at Westmead, Sydney, NSW 2145, Australia.
Gregory M RedpathEMBL Australia Node in Single Molecule Science, School of Medical Science, University of New South Wales, Sydney, NSW, Australia.
Frances A LemckertInstitute for Neuroscience and Muscle Research, Children's Hospital at Westmead, Sydney, NSW 2145, Australia.
Natalie WoolgerInstitute for Neuroscience and Muscle Research, Children's Hospital at Westmead, Sydney, NSW 2145, Australia; Discipline of Child and Adolescent Health, Faculty of Medicine, University of Sydney, Sydney, Australia.
Adam BournazosInstitute for Neuroscience and Muscle Research, Children's Hospital at Westmead, Sydney, NSW 2145, Australia.
Peter A GreerDepartment of Pathology and Molecular Medicine, Queen's University, Division of Cancer Biology and Genetics, Queen's Cancer Research Institute, Kingston, ON K7L 3N6, Canada.
Roger B SuttonDepartment of Cell Physiology and Molecular Biophysics, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA; Center for Membrane Protein Research, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.
Sandra T CooperInstitute for Neuroscience and Muscle Research, Children's Hospital at Westmead, Sydney, NSW 2145, Australia; Discipline of Child and Adolescent Health, Faculty of Medicine, University of Sydney, Sydney, Australia. Electronic address: sandra.cooper@sydney.edu.au.
Children's Hospital at Westmead · AUEMBL Australia · AUQueen's University · CATexas Tech University · USUniversity of Sydney · AU

Funding

Human dysferlin and its implications in Limb-Girdle Muscular DystrophyR01AR063634 · NIAMS · TEXAS TECH UNIVERSITY HEALTH SCIS CENTER · PI SUTTON, ROGER BRYAN · 2014 to 2018
$1.8M
CIHRNIAMS NIH HHS R01 AR063634
6 · The paper itself

Abstract

Myoferlin and dysferlin are closely related members of the ferlin family of Ca

Indexed as

MAP Kinase Signaling SystemAmino Acid SequenceAnimalsCalcium-Binding ProteinsCalpainCell Line, TumorDysferlinHEK293 CellsHumansMembrane ProteinsMiceModels, MolecularMuscle ProteinsPhosphorylationProtein DomainsProteolysisCalcium-Binding ProteinsCalpainDysferlinDYSF protein, humanMembrane ProteinsMuscle ProteinsMYOF protein, humanBreast cancerCalpainCell signallingExtracellular-signal-regulated kinase (ERK)MyoferlinProteolysis

Identifiers

PMID28192161
PMCPMC5995151
OpenAlexW2586189029

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.