ArticleThe Journal of allergy and clinical immunology2017
Systemic innate immune activation in food protein-induced enterocolitis syndrome.
Article in The Journal of allergy and clinical immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
48 citing papers in PubMed, 1 synthesis or guideline pooled it, 136 citations in OpenAlex.
- Achieving Precision Medicine in Allergic Disease: Progress and Challenges.Frontiers in immunology · 2021Pooled it
- When It Is Not NEC: Recognizing Mimics of Necrotizing Enterocolitis in Preterm Infants.Children (Basel, Switzerland) · 2026Review
- Diagnostic potential of allergen-specific lymphocyte stimulation test in hen's egg yolk-induced, food protein-induced enterocolitis syndrome.The journal of allergy and clinical immunology. Global · 2026Article
- Dupilumab opens a therapeutic window in food protein-induced enterocolitis syndrome by unlicensing dendritic cells.The journal of allergy and clinical immunology. Global · 2026Article
- Cytokine Variations After Positive Oral Food Challenges in Adult-Onset Food Protein-Induced Enterocolitis.Allergy · 2025Article
- Food Protein-Induced Enterocolitis Syndrome Across Lifespan: Focus on Adolescence.Journal of clinical medicine · 2025Review
- The Immunological Mechanisms Involved in the Pathophysiology of Allergic Proctocolitis.Children (Basel, Switzerland) · 2025Article
- Association of myeloid cell reactivity patterns with safe food predictions in FPIES patients.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2025Article
- Identification of Gut Biomarkers of FPIES in a Longitudinal Comparative Pediatric Study.Allergy · 2025Article
- Neonatal Food Protein-Induced Enterocolitis: Current Insights and Knowledge Gaps.Journal of clinical medicine · 2025Review
- The role of neutrophils in allergic disease.Clinical and experimental immunology · 2025Review
- Food protein-induced enterocolitis syndrome (FPIES) following COVID-19 infection: a case report.Frontiers in allergy · 2025Article
- Immunoglobulin-coating patterns reveal altered humoral responses to gut bacteria in pediatric cow milk allergies.Journal of translational medicine · 2024Article
- Contribution of T cell subsets to different food allergic diseases.Immunological reviews · 2024Review
- IgE and non-IgE food allergy: A review of immunological mechanisms.Journal of food allergy · 2024Article
- Effectiveness of continuous allergenic food intake for acute food protein-induced enterocolitis syndrome.The journal of allergy and clinical immunology. Global · 2024Article
- Mass Cytometry in Food Allergy Research.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Lymphocyte stimulation test for diagnosing hen's egg yolk-induced enterocolitis syndrome.The journal of allergy and clinical immunology. Global · 2023Article
- Pearls and pitfalls in food protein-induced enterocolitis syndrome (FPIES).Allergy and asthma proceedings · 2023Review
- A case report of acute food protein-induced enterocolitis syndrome to walnut.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundFood protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy of infancy whose pathophysiology is poorly understood.
objectivesWe set out to identify and phenotype allergen-responsive cells in peripheral blood of a cohort of subjects undergoing supervised food challenge for FPIES.
methodsWe profiled antigen-responsive cells in PBMCs by flow cytometry, and examined cells in whole blood obtained before and after challenge by CyTOF mass cytometry and RNAseq.
resultsUsing a CD154-based detection approach, we observed that milk, soy, or rice-responsive T cells, and TNF-α-producing CD154
conclusionsOur data demonstrate a compelling role of systemic innate immune activation in adverse reactions elicited by foods in FPIES. Further investigation is needed to identify the mechanism of antigen specificity of adverse reactions to foods in FPIES.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.