ArticleThe Journal of allergy and clinical immunology2017
Maternal house dust mite exposure during pregnancy enhances severity of house dust mite-induced asthma in murine offspring.
Article in The Journal of allergy and clinical immunology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Maternal asthma during pregnancy and risks of allergy and asthma in progeny: A systematic review and meta-analysis.BJOG : an international journal of obstetrics and gynaecology · 2025Pooled it
- Sex Differences in Asthma Pathogenesis.Immunological reviews · 2026Review
- Metabolomics reveals pro-inflammatory effects of 12R-HETE and ALOX12B in maternal allergic asthma.Communications biology · 2025Article
- Article
- Altered Fear Behavior in Aeroallergen House Dust Mite Exposed C57Bl/6 Mice: A Model of Th2-skewed Airway Inflammation.Neuroscience · 2023Article
- Blood eosinophil related to maternal allergic rhinitis is associated with the incidence of allergic rhinitis in offspring: COCOA study.BMC pediatrics · 2023Article
- IL-4Rα signalling in B cells and T cells play differential roles in acute and chronic atopic dermatitis.Scientific reports · 2023Article
- Unique Allergic Asthma Phenotypes in Offspring of House Dust Mite-exposed Mice.American journal of respiratory cell and molecular biology · 2022Article
- The Foetal Origins of Allergy and Potential Nutritional Interventions to Prevent Disease.Nutrients · 2022Review
- Exploring the evidence for epigenetic regulation of environmental influences on child health across generations.Communications biology · 2021Review
- Inflammatory mechanisms linking maternal and childhood asthma.Journal of leukocyte biology · 2020Review
- IL-5 ExposureAmerican journal of respiratory cell and molecular biology · 2020Article
- The Role of Dust Mites in Allergy.Clinical reviews in allergy & immunology · 2019Review
- Influences of Maternal Factors Over Offspring Allergies and the Application for Food Allergy.Frontiers in immunology · 2019Review
- Observational
- Environmental determinants of allergy and asthma in early life.The Journal of allergy and clinical immunology · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundAtopic status of the mother and maternal exposure to environmental factors are associated with increased asthma risk. Moreover, animal models demonstrate that exposure to allergens in strongly sensitized mothers influences offspring asthma development, suggesting that in utero exposures can influence offspring asthma. However, it is unclear whether maternal exposure to common human allergens such as house dust mite (HDM), in the absence of additional adjuvants, influences offspring asthma development.
objectiveWe sought to determine whether maternal HDM exposure influences asthma development in offspring.
methodsPregnant female mice were exposed to PBS or HDM during pregnancy. Using offspring of PBS- or HDM-exposed mothers, the magnitude of HDM or Aspergillus fumigatus (AF) extract-induced airway hyperresponsiveness (AHR), airway inflammation, immunoglobulin production, T
resultsCompared with offspring of PBS-exposed mothers, offspring of HDM-exposed mothers demonstrate increased AHR, airway inflammation, T
conclusionsOur data demonstrate that maternal exposure to HDM during pregnancy increases asthma sensitivity in offspring in an HDM-specific manner, suggesting that vertical transmission of maternal immune responses may be involved. These findings have important implications for regulation of asthma risk, and suggest that exposure to HDM in the developed world may have underappreciated influences on the overall prevalence of allergic asthma.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.