Evidence map›Paper›PMID 28192058›Full record

ReviewAnnual review of physiology2017

The Sodium/Iodide Symporter (NIS): Molecular Physiology and Preclinical and Clinical Applications.

Silvia Ravera, Andrea Reyna-Neyra, Giuseppe Ferrandino, L Mario Amzel, Nancy Carrasco

Open access · hybridAbstract readReview
In one paragraph

Review in Annual review of physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 158 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
158citing papers in PubMed, 3 pooled it
13.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

158 citing papers in PubMed, 3 syntheses or guidelines pooled it, 270 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Trial
  5. Review
  6. Review
  7. Article
  8. Sex and age at exposure influenceBiology of sex differences · 2026
    Article
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Observational
  16. Article
  17. Article
  18. Review
  19. Iodine Supplementation Before, During and After Pregnancy.Geburtshilfe und Frauenheilkunde · 2026
    Article
  20. PFAS Alter Thyroid Histology and Cellular SignalingJournal of the Endocrine Society · 2026
    Article

98 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Silvia RaveraDepartment of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, Connecticut 06510; email: nancy.carrasco@yale.edu.
Andrea Reyna-NeyraDepartment of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, Connecticut 06510; email: nancy.carrasco@yale.edu.
Giuseppe FerrandinoDepartment of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, Connecticut 06510; email: nancy.carrasco@yale.edu.
L Mario AmzelDepartment of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205.
Nancy CarrascoDepartment of Cellular and Molecular Physiology, Yale School of Medicine, New Haven, Connecticut 06510; email: nancy.carrasco@yale.edu.
Yale University · USJohns Hopkins Medicine · US

Funding

THYROID SODIUM I/ SYMPORTERR01DK041544 · NIDDK · YESHIVA UNIVERSITY · PI ABBOTT, GEOFFREY W, CARRASCO, NANCY · 1989 to 2017
$5.6M
Mechanism of I- transport by the Na+/l- symporter (NIS)R01GM114250 · NIGMS · YALE UNIVERSITY · PI Nancy Carrasco · 2016 to 2026
$4.8M
NIDDK NIH HHS R01 DK041544NIGMS NIH HHS R01 GM114250
6 · The paper itself

Abstract

Active iodide (I

Indexed as

AnimalsGenes, ReporterHumansIodidesSodium-Iodide SymportersSymportersThyroid GlandThyroid NeoplasmsIodidesSodium-Iodide SymportersSymportersgene transfer studiesimaging and radioiodide therapyNIS mutationssodium/iodide symporterstructure/functionthyroid hormones

Identifiers

PMID28192058
PMCPMC5739519
OpenAlexW2467366089

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.