ArticleNature medicine2017
Sirtuin 1 regulates cardiac electrical activity by deacetylating the cardiac sodium channel.
Open access · greenAbstract read
In one paragraph
Article in Nature medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed
5.9field-weighted citation impact, top 3% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 85 citations in OpenAlex.
- Dual Effects of Nicotinamide on Aging-Related Arrhythmia: Protective at Low Dose, Proarrhythmic at Higher Doses.Journal of the American Heart Association · 2026Article
- Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart.Journal of precision medicine (Amsterdam, Netherlands) · 2026Article
- Sodium Channel Isoform Diversity Underlies Chamber-Specific Cardiac Excitability.Circulation research · 2026Article
- Short SCN5A Transcript Yields a NaV1.5 Fragment Influencing Cardiac Metabolism.Circulation research · 2026Article
- Sodium Channel mRNA Binding Proteins.JACC. Basic to translational science · 2026Article
- Comparative transcriptomics analysis of histone deacetylases, transcription factors, and ion channel genes in human iPSC-cardiomyocytes vs. the adult human heart.bioRxiv : the preprint server for biology · 2026Article
- Cardiac intermediary metabolism in heart failure: substrate use, signalling roles and therapeutic targets.Nature reviews. Cardiology · 2025Review
- Voltage-Gated Sodium Channels: A Therapeutic Target in Ischemic Heart Disease.Reviews in cardiovascular medicine · 2025Review
- Diverse Physiological Roles of Kynurenine Pathway Metabolites: Updated Implications for Health and Disease.Metabolites · 2025Review
- Therapeutic Aspects of Melatonin-sirtuin Crosstalk: An Updated Review of Current Data Based on Cellular Mechanisms.Current drug targets · 2025Review
- Klotho enhances diastolic function in aged hearts through Sirt1-mediated pathways.GeroScience · 2024Article
- SIRT1 Ameliorates Lamin A/C Deficiency-Induced Cardiac Dysfunction by Promoting Mitochondrial Bioenergetics.JACC. Basic to translational science · 2024Article
- Nicotinamide Mononucleotide: Research Process in Cardiovascular Diseases.International journal of molecular sciences · 2024Review
- lncRNA CDKN2B-AS1 is downregulated in patients with ventricular fibrillation in acute myocardial infarction.PloS one · 2024Article
- SUMOylation of the cardiac sodium channel NaHeart rhythm · 2023Article
- The cardioprotective role of sirtuins is mediated in part by regulating KAmerican journal of physiology. Cell physiology · 2023Article
- From HDAC to Voltage-Gated Ion Channels: What's Next? The Long Road of Antiepileptic Drugs Repositioning in Cancer.Cancers · 2022Review
- Harnessing NADCurrent heart failure reports · 2022Review
- SIRT6 in Vascular Diseases, from Bench to Bedside.Aging and disease · 2022Article
- Metabolic rescue ameliorates mitochondrial encephalo-cardiomyopathy in murine and human iPSC models of Leigh syndrome.Clinical and translational medicine · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
27 authors at 5 institutions in 2 countries.
Ajit VikramDivision of Cardiovascular Medicine, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.ORCID http://orcid.org/0000-0003-3724-3842
Christopher M LewarchikUniversity of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Jin-Young YoonDivision of Cardiovascular Medicine, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Asma NaqviUniversity of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Santosh KumarDivision of Cardiovascular Medicine, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Gina M MorganDivision of Cardiovascular Medicine, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Julia S JacobsDivision of Cardiovascular Medicine, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Qiuxia LiDivision of Cardiovascular Medicine, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Young-Rae KimDivision of Cardiovascular Medicine, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Modar KassanDivision of Cardiovascular Medicine, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Jing LiuDivision of Cardiovascular Medicine, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Mohanad GabaniDivision of Cardiovascular Medicine, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Ajay KumarUniversity of Pittsburgh, Pittsburgh, Pennsylvania, USA.
Haider MehdiDivision of Cardiovascular Medicine, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Xiaodong ZhuDivision of Cardiovascular Medicine, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Xiaoqun GuanDivision of Cardiovascular Medicine, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
William KutschkeDivision of Cardiovascular Medicine, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Xiaoming ZhangDivision of Cardiovascular Medicine, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Ryan L BoudreauDivision of Cardiovascular Medicine, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Shengchuan DaiDivision of Cardiovascular Medicine, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Daniel S MatasicDivision of Cardiovascular Medicine, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Saet-Byel JungResearch Center for Endocrine and Metabolic Diseases, Chungnam National University School of Medicine, Daejeon, South Korea.
Kenneth B MarguliesCardiovascular Division, Department of Medicine, University of Pennsylvania, Perelman School of Medicine, Philadelphia, Pennsylvania, USA.
Vikas KumarVascular Biology Section, Cardiovascular Proteomics Center, Boston University School of Medicine, Boston, Massachusetts, USA.
Markus M BachschmidVascular Biology Section, Cardiovascular Proteomics Center, Boston University School of Medicine, Boston, Massachusetts, USA.ORCID http://orcid.org/0000-0002-0748-5528
Barry LondonDivision of Cardiovascular Medicine, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
Kaikobad IraniDivision of Cardiovascular Medicine, Department of Medicine, Abboud Cardiovascular Research Center, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA.
University of Iowa · USUniversity of Pittsburgh · USBoston University · USChungnam National University · KRUniversity of Pennsylvania · US
Funding
INTERDISCIPLINARY CARDIOVASCULAR RESEARCH FELLOWSHIPT32HL007121 · NHLBI · UNIVERSITY OF IOWA · PI LONDON, BARRY · 1985 to 2020
$15.1MSIRT1, Polyphenols, and Endothelial OxidantsP01HL068758 · NHLBI · BOSTON MEDICAL CENTER · PI WALSH, KENNETH · 2003 to 2013
$14.1MIntegrative genomics of human heart failureR01HL105993 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ASHLEY, EUAN A, CAPPOLA, THOMAS P. · 2011 to 2014
$8.9MPROGRAM IN HEMOSTASIS AND THROMBOSIS FOR ACADEMICT32HL007344 · NHLBI · UNIVERSITY OF IOWA · PI Anil Kumar Chauhan, Steven R Lentz · 1985 to 2026
$6.5MSUMOylation of Voltage-Gated Sodium Channels In Neuronal Hyperexcitability of Alzheimer’s DementiaR01HL115955 · NHLBI · UNIVERSITY OF IOWA · PI IRANI, KAIKOBAD J., LONDON, BARRY · 2013 to 2023
$5.4MRedox Regulation of p21ras in AngiogenesisR37HL104017 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI COHEN, RICHARD A · 2010 to 2014
$2.2MRedox Control of Hepatic Lipid MetabolismR01DK103750 · NIDDK · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BACHSCHMID, MARKUS MICHAEL · 2015 to 2019
$1.8MHigh-Resolution Research UltrasoundS10OD019941 · OD · UNIVERSITY OF IOWA · PI WEISS, ROBERT M · 2015 to 2015
$298kNHLBI NIH HHS P01 HL068758NHLBI NIH HHS R01 HL105993NHLBI NIH HHS R01 HL115955NHLBI NIH HHS R37 HL104017NHLBI NIH HHS T32 HL007121NHLBI NIH HHS T32 HL007344NIDDK NIH HHS R01 DK103750
Abstract
The voltage-gated cardiac Na
Indexed as
Action PotentialsMembrane PotentialsAcetylationAnimalsArrhythmias, CardiacCardiomyopathiesEchocardiographyElectrocardiographyHeartHEK293 CellsHumansImmunoblottingImmunoprecipitationMass SpectrometryMiceMice, KnockoutNAV1.5 Voltage-Gated Sodium ChannelSCN5A protein, humanScn5a protein, mouseSirt1 protein, mouseSirtuin 1
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.