Evidence map›Paper›PMID 28191877›Full record

Trial reportPhysics in medicine and biology2017

A virtual clinical trial comparing static versus dynamic PET imaging in measuring response to breast cancer therapy.

Kristen A Wangerin, Mark Muzi, Lanell M Peterson, Hannah M Linden, Alena Novakova, David A Mankoff, Paul E Kinahan

Abstract readClinical Trial
In one paragraph

Trial report in Physics in medicine and biology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. An integrated PET/CT simulation framework for virtual imaging trials and quantitative performance evaluation.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2026
    Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Virtual clinical trials in medical imaging: a review.Journal of medical imaging (Bellingham, Wash.) · 2020
    Review
  7. Article
  8. Does whole-body PatlakEuropean radiology · 2019
    Article
  9. Quantitative Analysis of Heterogeneous [Molecular imaging and biology · 2019
    Article
  10. Imaging and Molecular Mechanisms of Alzheimer's Disease: A Review.International journal of molecular sciences · 2018
    Review
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kristen A WangerinDepartment of Bioengineering, University of Washington, 3720 15th Avenue NE, Seattle, 98195 WA, United States of America.
Mark MuziDepartment of Radiology, University of Washington, 1959 NE Pacific Street, Seattle, 98195 WA, United States of America.
Lanell M PetersonDepartment of Radiology, University of Washington, 1959 NE Pacific Street, Seattle, 98195 WA, United States of America.
Hannah M LindenDepartment of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, 98195 WA, United States of America.
Alena NovakovaDepartment of Medicine, University of Washington, 1959 NE Pacific Street, Seattle, 98195 WA, United States of America.
David A MankoffDepartment of Radiology, University of Pennsylvania, 3400 Spruce Street, Philadelphia, 19104 PA, United States of America.
Paul E KinahanDepartment of Bioengineering, University of Washington, 3720 15th Avenue NE, Seattle, 98195 WA, United States of America.

Funding

RadiochemistryP01CA042045 · NCI · UNIVERSITY OF WASHINGTON · PI LINK, JEANNE MEYERS · 1986 to 2015
$23.2M
Targeted immunotherapy of breast cancer with central memory T cellsP50CA138293 · NCI · FRED HUTCHINSON CANCER RESEARCH CENTER · PI PORTER, PEGGY L. · 2010 to 2014
$11.0M
Advanced PET/CT Imaging for Improving Clinical TrialsU01CA148131 · NCI · UNIVERSITY OF WASHINGTON · PI KINAHAN, PAUL E., LINDEN, HANNAH M · 2010 to 2019
$6.0M
IMAGING THE RESPONSE OF LOCALLY ADVANCED BREAST CANCERR01CA072064 · NCI · UNIVERSITY OF WASHINGTON · PI MANKOFF, DAVID A. · 1996 to 2006
$3.1M
Core Laboratory for Advanced PET and MRI image analysisR50CA211270 · NCI · UNIVERSITY OF WASHINGTON · PI Mark Muzi · 2017 to 2026
$2.6M
Measures of Endocrine Sensitivity in Early Breast CancerRC1CA146456 · NCI · UNIVERSITY OF WASHINGTON · PI LINDEN, HANNAH M · 2009 to 2010
$954k
NCI NIH HHS P01 CA042045NCI NIH HHS P50 CA138293NCI NIH HHS R01 CA072064NCI NIH HHS R50 CA211270NCI NIH HHS RC1 CA146456NCI NIH HHS U01 CA148131
6 · The paper itself

Abstract

We developed a method to evaluate variations in the PET imaging process in order to characterize the relative ability of static and dynamic metrics to measure breast cancer response to therapy in a clinical trial setting. We performed a virtual clinical trial by generating 540 independent and identically distributed PET imaging study realizations for each of 22 original dynamic fluorodeoxyglucose (

Indexed as

AgedAged, 80 and overBreast NeoplasmsComputer SimulationFemaleFluorodeoxyglucose F18HumansImage Interpretation, Computer-AssistedMiddle AgedPositron-Emission TomographyRadiopharmaceuticalsFluorodeoxyglucose F18Radiopharmaceuticals

Identifiers

PMID28191877
PMCPMC5713892

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.