Evidence map›Paper›PMID 28191768›Full record

ArticleStem cells translational medicine2017

Multimodal Delivery of Isogenic Mesenchymal Stem Cells Yields Synergistic Protection from Retinal Degeneration and Vision Loss.

Benjamin Bakondi, Sergey Girman, Bin Lu, Shaomei Wang

Open access · goldAbstract read
In one paragraph

Article in Stem cells translational medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Stem cell therapies for retinal diseases: from bench to bedside.Journal of molecular medicine (Berlin, Germany) · 2020
    Review
  8. Review
  9. Article
  10. Article
  11. Review
  12. Review
  13. Recent Advances in Retinal Stem Cell Therapy.Current molecular biology reports · 2017
    Article
  14. Review
  15. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Benjamin BakondiBoard of Governors Regenerative Medicine Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Sergey GirmanBoard of Governors Regenerative Medicine Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Bin LuBoard of Governors Regenerative Medicine Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Shaomei WangBoard of Governors Regenerative Medicine Institute, Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Cedars-Sinai Medical Center · US

Funding

Development of non-invasive cell-based therapy for retinal degeneration and assocR01EY020488 · NEI · CEDARS-SINAI MEDICAL CENTER · PI WANG, SHAOMEI · 2011 to 2015
$1.6M
NEI NIH HHS R01 EY020488
6 · The paper itself

Abstract

We previously demonstrated that subretinal injection (SRI) of isogenic mesenchymal stem cells (MSCs) reduced the severity of retinal degeneration in Royal College of Surgeons rats in a focal manner. In contrast, intravenous MSC infusion (MSC

Indexed as

RetinaVision, OcularAnimalsCell MovementCells, CulturedCell SeparationChemokine CXCL12Disease Models, AnimalMesenchymal Stem CellsMesenchymal Stem Cell TransplantationParacrine CommunicationPhagocytosisPhotoreceptor Cells, VertebrateRatsRetinal DystrophiesRetinal Pigment EpitheliumChemokine CXCL12Age-related macular degenerationImmunosuppressionMesenchymal stem cell transplantationRetinal pigment epitheliumRetinitis pigmentosaStromal derived factor-1αTranslational researchTrophic factor receptors

Identifiers

PMID28191768
PMCPMC5442813
OpenAlexW2509036775

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.