ArticleMolecular nutrition & food research2017
Bioinformatic screening and detection of allergen cross-reactive IgE-binding epitopes.
Article in Molecular nutrition & food research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 39 citations in OpenAlex.
- Article
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- Mapping the major B-cell linear epitope of silkworm (Frontiers in immunology · 2026Article
- Linear and conformational epitopes of vicilin-buried peptides as a model for improved nut allergy diagnostics.Frontiers in allergy · 2025Article
- Co-sensitization between legumes is frequently seen, but variable and not always clinically relevant.Frontiers in allergy · 2023Article
- Biochemical and clinical studies of putative allergens to assess what distinguishes them from other non-allergenic proteins in the same family.Transgenic research · 2022Article
- The Identification and Characterization of Immunoreactive Fungal Proteins Recognized by Sera from Zimbabweans Sensitized to Fungi.International archives of allergy and immunology · 2022Article
- Mapping B-Cell Epitopes for Nonspecific Lipid Transfer Proteins of Legumes Consumed in India and Identification of Critical Residues Responsible for IgE Binding.Foods (Basel, Switzerland) · 2021Article
- Proteome-wide analysis of Coxiella burnetii for conserved T-cell epitopes with presentation across multiple host species.BMC bioinformatics · 2021Article
- Allergens from Edible Insects: Cross-reactivity and Effects of Processing.Current allergy and asthma reports · 2021Review
- Comparative evaluation of the immunodominant proteins ofVeterinary world · 2021Article
- Article
- Bioinformatic screening and detection of allergen cross-reactive IgE-binding epitopes.Molecular nutrition & food research · 2017Article
- AllerBase: a comprehensive allergen knowledgebase.Database : the journal of biological databases and curation · 2017Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Protein allergens can be related by cross-reactivity. Allergens that share relevant sequence can cross-react, those lacking sufficient similarity in their IgE antibody-binding epitopes do not cross-react. Cross-reactivity is based on shared epitopes that is based on shared sequence and higher level structure (charge and shape). Epitopes are important in predicting cross-reactivity potential and may provide the potential to establish criteria that identify homology among allergens. Selected allergen's IgE-binding epitope sequences were used to determine how the FASTA algorithm could be used to identify a threshold of significance. A statistical measure (expectation value, E-value) was used to identify a threshold specific to identifying cross-reactivity potential. Peanut Ara h 1 and Ara h 2, shrimp tropomyosin Pen a 1, and birch tree pollen allergen, Bet v 1 were sources of known epitopes. Each epitope or set of epitopes was inserted into random amino acid sequence to create hypothetical proteins used as queries to an allergen database. Alignments with allergens were noted for the ability to match the epitope's source allergen as well as any cross-reactive or other homologous allergens. A FASTA expectation value range (1 × 10
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