ArticleJournal of translational internal medicine2016
Metabolic acidosis status and mortality in patients on the end stage of renal disease.
Article in Journal of translational internal medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 20 citations in OpenAlex.
- Rethinking protein choices: the association between the isocaloric substitution of dietary protein sources and dietary acid load in hemodialysis patients: a cross-sectional study.BMC nutrition · 2026Article
- Impact of decreased levels of total CO2 on in-hospital mortality in patients with COVID-19.Scientific reports · 2023Article
- Longitudinal trajectory of acidosis and mortality in acute kidney injury requiring continuous renal replacement therapy.BMC nephrology · 2022Article
- Article
- Acid base disorders in patients with COVID-19.International urology and nephrology · 2022Article
- Nutritional Approaches for the Management of Metabolic Acidosis in Chronic Kidney Disease.Nutrients · 2021Review
- Pathway and application value of exploration of the pulmonary artery by endobronchial ultrasound.Journal of thoracic disease · 2017Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND AND
objectivesUncorrected metabolic acidosis leads to higher death risk in dialysis patients. We observed the relationship between metabolic acidosis status and mortality rate in patients on renal replacement therapy during a median follow up time of 60 months.
methodsWe studied 76 patients on an on-line hemodiafiltration. The dialysis adequacy was defined by Kt/V for urea. The Framingham risk score (FRS) points were used to determine the 10-year risk for coronary heart disease. We examined the impact of high or low serum bicarbonate concentrations on mortality rate and on 10-year risk for coronary heart disease via the Kaplan-Meier method. Cox's model was used to evaluate a combination of prognostic variables, such as dialysis adequacy defined by Kt/V for urea, age and serum bicarbonate concentrations.
resultsWe divided the enrolled patients in three groups according to serum bicarbonate concentrations (< 20 mmol/L, 20-22 mmol/L and > 22 mmol/L). Kaplan-Meier survival curve for the impact of serum bicarbonate concentrations on overall mortality was found significant (log-rank = 7.8,
conclusionUncorrected severe metabolic acidosis, defined by serum bicarbonate concentrations less than 20 mmol/L, is associated with a 10-year risk for coronary heart disease more than 20% and high overall mortality in patients on renal replacement therapy.
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Registered trials
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