Evidence map›Paper›PMID 28191438›Full record

ReviewNano convergence2016

Progress and challenges of the bioartificial pancreas.

Patrick T J Hwang, Dishant K Shah, Jacob A Garcia, Chae Yun Bae, Dong-Jin Lim, Ryan C Huiszoon, Grant C Alexander, Ho-Wook Jun

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Nano convergence, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Review
  9. Article
  10. Islet cell encapsulation - Application in diabetes treatment.Experimental biology and medicine (Maywood, N.J.) · 2021
    Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. Review
  16. It's All in the Delivery: Designing Hydrogels for Cell and Non-viral Gene Therapies.Molecular therapy : the journal of the American Society of Gene Therapy · 2018
    Review
  17. Article
  18. Encapsulated Islet Transplantation: Where Do We Stand?The review of diabetic studies : RDS · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Patrick T J HwangDepartment of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294 USA.
Dishant K ShahDepartment of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294 USA.
Jacob A GarciaDepartment of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294 USA.
Chae Yun BaeDepartment of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294 USA.
Dong-Jin LimDepartment of Otolaryngology, University of Alabama at Birmingham, Boshell, 1720 2nd Avenue South, Birmingham, AL 35294 USA.
Ryan C HuiszoonDepartment of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294 USA.
Grant C AlexanderDepartment of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294 USA.
Ho-Wook JunDepartment of Biomedical Engineering, University of Alabama at Birmingham, Birmingham, AL 35294 USA ; 806 Shelby, 1825 University Boulevard, Birmingham, AL USA.

Funding

Prohealing multifunctional endothelium nanomatrix coated stentR01HL125391 · NHLBI · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JUN, HO-WOOK · 2015 to 2019
$1.8M
A hybrid nanosack for the enhanced islet engraftment in the omentumR03EB017344 · NIBIB · UNIVERSITY OF ALABAMA AT BIRMINGHAM · PI JUN, HO-WOOK · 2013 to 2014
$143k
NHLBI NIH HHS R01 HL125391NIBIB NIH HHS R03 EB017344
6 · The paper itself

Abstract

Pancreatic islet transplantation has been validated as a treatment for type 1 diabetes since it maintains consistent and sustained type 1 diabetes reversal. However, one of the major challenges in pancreatic islet transplantation is the body's natural immune response to the implanted islets. Immunosuppressive drug treatment is the most popular immunomodulatory approach for islet graft survival. However, administration of immunosuppressive drugs gives rise to negative side effects, and long-term effects are not clearly understood. A bioartificial pancreas is a therapeutic approach to enable pancreatic islet transplantation without or with minimal immune suppression. The bioartificial pancreas encapsulates the pancreatic islets in a semi-permeable environment which protects islets from the body's immune responses, while allowing the permeation of insulin, oxygen, nutrients, and waste. Many groups have developed various types of the bioartificial pancreas and tested their efficacy in animal models. However, the clinical application of the bioartificial pancreas still requires further investigation. In this review, we discuss several types of bioartificial pancreases and address their advantages and limitations. We also discuss recent advances in bioartificial pancreas applications with microfluidic or micropatterning technology.

Indexed as

Bioartificial pancreasIslet surface modificationMacroencapsulationMicroencapsulationMicrofluidicMicropatterning

Identifiers

PMID28191438
PMCPMC5271153

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.