Evidence map›Paper›PMID 28191332›Full record

ArticleIranian Red Crescent medical journal2016

Angiotensin II Type 1 Receptor Gene A1166C Polymorphism Was Not Associated With Acute Coronary Syndrome in an Iranian Population.

Navid Delshad, Majid Ghayour-Mobarhan, Hamed Mirzaei, Kamal Razavi-Azarkhiavi, Mohsen Moohebati, Mitra Hassany, Jamal Kasaian, Mohammad Reza Etemadzadeh, Maryam Sadat Alavi, Javad Behravan

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In one paragraph

Article in Iranian Red Crescent medical journal, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.2field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Navid DelshadBiotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran.
Majid Ghayour-MobarhanCardiovascular Research Center, Avicenna Research institute, Mashhad University of Medical Sciences, Mashhad, IR Iran; Biochemistry and Nutrition Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran.
Hamed MirzaeiDepartment of Medical Biotechnology, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran.
Kamal Razavi-AzarkhiaviDepartment of Pharmacodynamics and Toxicology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran.
Mohsen MoohebatiDepartment of Cardiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran.
Mitra HassanyBiotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran.
Jamal KasaianBiotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran.
Mohammad Reza EtemadzadehCardiovascular Research Center, Avicenna Research institute, Mashhad University of Medical Sciences, Mashhad, IR Iran; Department of Cardiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran.
Maryam Sadat AlaviCardiovascular Research Center, Avicenna Research institute, Mashhad University of Medical Sciences, Mashhad, IR Iran; Department of Cardiology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, IR Iran.
Javad BehravanBiotechnology Research Center, Mashhad University of Medical Sciences, Mashhad, IR Iran; Department of Pharmaceutical Biotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, IR Iran.
Mashhad University of Medical Sciences · IRBiotechnology Research Center · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThere are very limited data for Iranian populations on the predisposing genetic factors for acute coronary syndrome (ACS).

objectivesThe objective of the present study was to investigate the association of the angiotensin II type 1 receptor (AT1R) gene polymorphism and ACS in an Iranian population. PATIENTS AND

methodsThis cross-sectional study was conducted among 263 subjects (97 men and 166 women). Patients (n = 128) aged 30 - 80 years with chest pain were recruited from the emergency department of Ghaem Hospital (Mashhad, Iran). A 12-lead electrocardiograph plus creatine kinase MB (CK-MB) levels were used as the basis for the diagnosis of myocardial ischemia. The control group was selected from age-matched healthy subjects (n = 135). Non-enzymatic kits were used for extraction of DNA from blood samples. Polymerase chain reaction (PCR) was performed to amplify the DNA fragments. For restriction fragment length polymorphism (RFLP) determination, the DdeI enzyme was used to digest the amplified DNA fragments. Statistical analyses were performed using SPSS version 13.0.

resultsThere was no statistical difference in the genotype frequency of patients and healthy subjects with regard to age and gender (P > 0.05).

conclusionsThe AT1R A1166C polymorphism appeared not to be associated with the presence of ACS in the population studied.

Indexed as

Acute Coronary SyndromeAngiotensin II Type 1 ReceptorAT1R A1166CGene PolymorphismsGenotype Frequency

Identifiers

PMID28191332
PMCPMC5292135
OpenAlexW2471470732

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.