ArticleClinical hypertension2017
Autonomic imbalance captures maternal and fetal circulatory response to pre-eclampsia.
Article in Clinical hypertension, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Multi-Organ Phenotypes of Offspring Born Following Hypertensive Disorders of Pregnancy: A Systematic Review.Journal of the American Heart Association · 2024Pooled it
- Autonomic Dysfunction in Preeclampsia: A Systematic Review.Frontiers in neurology · 2019Pooled it
- Antepartum Computerized Cardiotocography in High-Risk Pregnancies: Comparative Analysis of Fetal Heart Rate Parameters in Hypertensive Disorders of Pregnancy, Diabetes and Intrahepatic Cholestasis.Journal of clinical medicine · 2026Article
- Transcutaneous Auricular Vagus Nerve Stimulation Ameliorates Preeclampsia-Induced Apoptosis of Placental Trophoblastic Cells Via Inhibiting the Mitochondrial Unfolded Protein Response.Neuroscience bulletin · 2024Article
- Editorial: The repercussions of maternal inflammation in pre-eclampsia on fetal health and neurodevelopment.Frontiers in immunology · 2024Article
- Analysis of fetal heart rate fluctuations in women diagnosed with preeclampsia during the latent phase of labor.Frontiers in physiology · 2024Article
- Increased respiratory modulation of cardiovascular control reflects improved blood pressure regulation in pregnancy.Frontiers in physiology · 2023Article
- Changes in the autonomic cardiorespiratory activity in parturient women with severe and moderate features of preeclampsia.Frontiers in immunology · 2023Article
- Evidence and clinical relevance of maternal-fetal cardiac coupling: A scoping review.PloS one · 2023Article
- Nonlinear analysis of heart rhythm in preeclampsia: a route for translational clinical applications in neuroinflammation.Clinical hypertension · 2021Review
- A review of fetal cardiac monitoring, with a focus on low- and middle-income countries.Physiological measurement · 2020Review
- Heart Rate Variability in the Perinatal Period: A Critical and Conceptual Review.Frontiers in neuroscience · 2020Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPre-eclampsia (PE) is a gestational disease featured by hypertension, arterial systemic vasculopathy, multiple organ failure and fetal compromise. The aim of the investigation was to determine the role of maternal respiratory sinus arrhythmia (RSA) in regulation of the fetal circulatory system in case of healthy pregnancy and in PE.
methodsThe investigation of maternal and fetal HRV and fetal CTG variables in 106 patients at 34-40 weeks of gestation was performed. 30 of them had healthy pregnancy and were involved in the Group I. In Group II 44 pregnant women with mild-moderate PE were observed. 32 patients with severe PE were monitored in Group III.
resultThe maternal sympathetic overactivity modulated HRV in PE by suppressing total power (TP) and parasympathetic tone. The lack of RSA was explored in preeclamptic patients. The centralization of hemodynamics was a result of the hypersympatheticotonia in severe PE. Fetal circulatory response to PE featured by an increased sympathetic tone. The modulated fetal CTG variables captured the suppression of fetal biophysical activity and the development of fetal distress in severe PE. Strong relationship between maternal and fetal TPs, maternal and fetal RMSSDs was found in healthy pregnancy. The correlations between the maternal and fetal TPs, the maternal and fetal RMSSDs in the patients with severe PE were disturbed.
conclusionThe maternal RSA propagated its influence on the fetal autonomic nervous regulation in normal gestation. The maternal and fetal hemodynamic coupling was reduced in PE.
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