ArticleBasic and clinical andrology2017
The contraceptive efficacy of intravas injection of Vasalgel™ for adult male rhesus monkeys.
Article in Basic and clinical andrology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Evaluation of a Zinc Gluconate Neutralized with Arginine Product as a Nonsurgical Method for Sterilization of Rhesus Macaques (Journal of the American Association for Laboratory Animal Science : JAALAS · 2017Trial
- Novel male contraceptives.Future science OA · 2026Review
- Non-human primates as a translational model for the study of male reproductive health.Nature reviews. Urology · 2025Review
- Hydrogels in Contraceptive Applications and Their Mechanisms of Action.ACS applied bio materials · 2025Review
- Non-hormonal Contraception: Current and Emerging Targets.Advances in experimental medicine and biology · 2025Review
- Advances in Male Contraception: When Will the Novel Male Contraception be Available?The world journal of men's health · 2024Review
- Current global status of male reproductive health.Human reproduction open · 2024Review
- Male contraception: narrative review of ongoing research.Basic and clinical andrology · 2023Review
- A brief history and future prospects of contraception.Science (New York, N.Y.) · 2023Review
- Emerging approaches to male contraception.Fertility and sterility · 2021Review
- Update on Novel Hormonal and Nonhormonal Male Contraceptive Development.The Journal of clinical endocrinology and metabolism · 2021Review
- Male Contraception.The Yale journal of biology and medicine · 2020Review
- Development of Novel Male Contraceptives.Clinical and translational science · 2020Review
- Male contraception: where are we going and where have we been?BMJ sexual & reproductive health · 2019Review
- Article
- The future of male contraception: a fertile ground.Translational andrology and urology · 2018Review
- Retrospective Review of Surgical Outcomes and Pair-housing Success in Vasectomized Rhesus Macaques (Comparative medicine · 2018Article
- Modeling the impact of novel male contraceptive methods on reductions in unintended pregnancies in Nigeria, South Africa, and the United States.Contraception · 2018Article
- Inhibition of sperm motility in male macaques with EP055, a potential non-hormonal male contraceptive.PloS one · 2018Article
- Emerging concepts in male contraception: a narrative review of novel, hormonal and non-hormonal options.Therapeutic advances in reproductive healthReview
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
backgroundOptions for male contraception are limited. The purpose of this study was to use a nonhuman primate model to evaluate Vasalgel™, a high molecular weight polymer being developed as a contraceptive device for men.
methodsSixteen adult male rhesus monkeys received intravas injections of Vasalgel, consisting of 25% styrene maleic acid in dimethyl sulfoxide. After a one-week recovery, males were returned to outdoor group housing, which included at least 3 and up to 9 intact, breeding females with a successful reproductive history.
resultsTreated males have had no conceptions since Vasalgel injections. All males were housed with intact females for at least one breeding season and seven have been almost continually housed with females for 2 years. Complications were minor and included one incident of incorrect placement of Vasalgel into the vas deferens and the development of a sperm granuloma in one animal. Three unilateral vasectomies were performed, one was necessary for incorrect placement of Vasalgel, the other two were elective.
conclusionsIntravas injection of Vasalgel in sexually mature adult male rhesus monkeys was effective in preventing conception in a free-living, group environment. Complications were few and similar to those associated with traditional vasectomy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.