ArticleOxidative medicine and cellular longevity2017
Pathway-Driven Approaches of Interaction between Oxidative Balance and Genetic Polymorphism on Metabolic Syndrome.
Article in Oxidative medicine and cellular longevity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- A Review ofNutrients · 2019Pooled it
- Phthalate and Terephthalate Mixtures, Cardiometabolic Risk Factors, and the Role of Oxidative Stress: Evidence from NHANES 2015-2018.Cardiovascular toxicology · 2026Article
- Association of Nutrient-, Food-, and Lifestyle-Based Oxidative Balance Scores with Liver Enzymes in Older Adults Across Cardiovascular-Risk Groups.Antioxidants (Basel, Switzerland) · 2026Article
- Oxidative balance scores and overactive bladder: mediating effects of oxidative stress and inflammatory factors.BMC urology · 2025Article
- Association between the oxidative balance score and diabetic kidney disease in diabetes mellitus patients: insights from NHANES 2011-2018.Frontiers in nutrition · 2025Article
- Effects of the Interaction Between Oxidative Balance Score and Polygenic Risk Scores on Incidence of Metabolic Syndrome in Middle-Aged Korean Adults.Antioxidants (Basel, Switzerland) · 2024Article
- Association between the oxidative balance score with metabolic syndrome traits in US adults.Diabetology & metabolic syndrome · 2024Article
- The association between sleep quality and accelerated epigenetic aging with metabolic syndrome in Korean adults.Clinical epigenetics · 2024Article
- The relationship between oxidative balance scores and chronic diarrhea and constipation: a population-based study.BMC public health · 2024Article
- Association between dietary and behavioral-based oxidative balance score and phenotypic age acceleration: a cross-sectional study of Americans.Epidemiology and health · 2024Article
- Association between the oxidative balance score and low muscle mass in middle-aged US adults.Frontiers in nutrition · 2024Article
- Association of the oxidative balance score with obesity and body composition among young and middle-aged adults.Frontiers in nutrition · 2024Article
- Oxidative stress and inflammation mediate the association between elevated oxidative balance scores and improved sleep quality: evidence from NHANES.Frontiers in nutrition · 2024Article
- Relationship between oxidative balance score and post-stroke depression: insights from the NHANES 2005-2018 cross-sectional study.Frontiers in neurology · 2024Article
- Serum total bilirubin and one-year prognosis of patients with coronary artery disease and psoriasis.iScience · 2023Article
- Adherence to oxidative balance scores and lower odds of non-alcoholic fatty liver disease: a case-control study.Scientific reports · 2023Article
- Oxidative balance score was negatively associated with the risk of metabolic syndrome, metabolic syndrome severity, and all-cause mortality of patients with metabolic syndrome.Frontiers in endocrinology · 2023Article
- Oxidative balance score inversely associated with the prevalence and incidence of metabolic syndrome: analysis of two studies of the Korean population.Frontiers in nutrition · 2023Article
- Oxidative Balance Scores (OBSs) Integrating Nutrient, Food and Lifestyle Dimensions: Development of the NutrientL-OBS and FoodL-OBS.Antioxidants (Basel, Switzerland) · 2022Article
- Association between the Oxidative Balance Score and Telomere Length from the National Health and Nutrition Examination Survey 1999-2002.Oxidative medicine and cellular longevity · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite evidences of association between basic redox biology and metabolic syndrome (MetS), few studies have evaluated indices that account for multiple oxidative effectors for MetS. Oxidative balance score (OBS) has indicated the role of oxidative stress in chronic disease pathophysiology. In this study, we evaluated OBS as an oxidative balance indicator for estimating risk of MetS with 6414 study participants. OBS is a multiple exogenous factor score for development of disease; therefore, we investigated interplay between oxidative balance and genetic variation for development of MetS focusing on biological pathways by using gene-set-enrichment analysis. As a result, participants in the highest quartile of OBS were less likely to be at risk for MetS than those in the lowest quartile. In addition, persons in the highest quartile of OBS had the lowest level of inflammatory markers including C-reactive protein and WBC. With GWAS-based pathway analysis, we found that VEGF signaling pathway, glutathione metabolism, and Rac-1 pathway were significantly enriched biological pathways involved with OBS on MetS. These findings suggested that mechanism of angiogenesis, oxidative stress, and inflammation can be involved in interaction between OBS and genetic variation on risk of MetS.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.