Evidence map›Paper›PMID 28191017›Full record

ArticleStem cells international2017

Mouse Mesenchymal Progenitor Cells Expressing Adipogenic and Osteogenic Transcription Factors Suppress the Macrophage Inflammatory Response.

Natalie Fernandez, Heather Renna, Lauren McHugh, Katie Mazalkova, William Crugnola, Jodi F Evans

Erratum issuedOpen access · goldAbstract read
In one paragraph

Article in Stem cells international, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Natalie FernandezDepartment of Biology, Chemistry and Environmental Studies, Molloy College, 1000 Hempstead Avenue, Rockville Centre, NY 11570, USA; Biomedical Research Core, Winthrop University Hospital, 101 Mineola Blvd., Mineola, NY 11501, USA.
Heather RennaDepartment of Biology, Chemistry and Environmental Studies, Molloy College, 1000 Hempstead Avenue, Rockville Centre, NY 11570, USA; Biomedical Research Core, Winthrop University Hospital, 101 Mineola Blvd., Mineola, NY 11501, USA.
Lauren McHughDepartment of Biology, Chemistry and Environmental Studies, Molloy College, 1000 Hempstead Avenue, Rockville Centre, NY 11570, USA.
Katie MazalkovaDepartment of Biology, Chemistry and Environmental Studies, Molloy College, 1000 Hempstead Avenue, Rockville Centre, NY 11570, USA.
William CrugnolaDepartment of Biology, Chemistry and Environmental Studies, Molloy College, 1000 Hempstead Avenue, Rockville Centre, NY 11570, USA.
Jodi F EvansDepartment of Biology, Chemistry and Environmental Studies, Molloy College, 1000 Hempstead Avenue, Rockville Centre, NY 11570, USA; Biomedical Research Core, Winthrop University Hospital, 101 Mineola Blvd., Mineola, NY 11501, USA; Stony Brook University School of Medicine, Stony Brook, NY 11794, USA.ORCID 0000-0002-6404-7604
Molloy College · USWinthrop-University Hospital · US

Funding

Stress Hormones and Chondrogenic Vascular CalcificationR00HL091116 · NHLBI · NYU WINTHROP HOSPITAL · PI EVANS, JODI FRANCES · 2012 to 2014
$730k
NHLBI NIH HHS R00 HL091116
6 · The paper itself

Abstract

Mesenchymal progenitor cell characteristics that can identify progenitor populations with specific functions in immunity are actively being investigated. Progenitors from bone marrow and adipose tissue regulate the macrophage (MΦ) inflammatory response by promoting the switch from an inflammatory to an anti-inflammatory phenotype. Conversely, mesenchymal progenitors from the mouse aorta (mAo) support and contribute to the MΦ response under inflammatory conditions. We used cell lines with purported opposing immune-regulatory function, a bone marrow derived mesenchymal progenitor cell line (D1) and a mouse aorta derived mesenchymal progenitor cell line (mAo). Their interaction and regulation of the MΦ cell response to the inflammatory mediator, lipopolysaccharide (LPS), was examined by coculture. As expected, D1 cells suppressed NO, TNF-

Identifiers

PMID28191017
PMCPMC5278224
OpenAlexW2579733777

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.