ArticleJournal of toxicologic pathology2017
Malignant mast cell tumor of the thymus in an Royal College of Surgeons (RCS) rat.
Article in Journal of toxicologic pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
4 citing papers in PubMed, 7 citations in OpenAlex.
- Cutaneous Mast Cell Tumor With Metastasis in a Pet Cairo Spiny Mouse (Case reports in veterinary medicine · 2026Article
- Gastrointestinal Mast Cell Tumor in an African Dormouse (Veterinary sciences · 2022Article
- Proceedings of the 2019 National Toxicology Program Satellite Symposium.Toxicologic pathology · 2019Article
- Spontaneous globule leukocyte tumor accompanied by inflammatory cells in a Wistar Hannover rat.Journal of toxicologic pathology · 2019Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 152-week-old male Royal College of Surgeons (RCS) rat kept as a non-treated animal in a long-term animal study presented with a soft mass in the anterior mediastinum, which adhered to the pleura of the lung. Histopathologically, the mass mainly consisted of round to short spindle-shaped tumor cells that had infiltrated through the hyperplastic thymic tissue. The tumor cells were arranged in loose to dense sheets. Nuclei were moderate in size and round to spindle-shaped, with small nucleoli. Almost all tumor cells exhibited abundant eosinophilic cytoplasm, including eosinophilic granules of a range of sizes. The granules of tumor cells exhibited metachromasia with toluidine blue stain and were positive for c-kit and mast cell protease II. These findings indicate that the tumor described here represents a rare case of spontaneous malignant mast cell tumor with thymic epithelial hyperplasia.
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