ReviewMedical science monitor : international medical journal of experimental and clinical research2017
The Role of Uric Acid in Hypertension of Adolescents, Prehypertension and Salt Sensitivity of Blood Pressure.
Review in Medical science monitor : international medical journal of experimental and clinical research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 42 citations in OpenAlex.
- Pooled it
- Association of Uric Acid in Serum and Urine with Arterial Stiffness: Hanzhong Adolescent Hypertension Study.Disease markers · 2020Trial
- Effect of Salt Intake on Plasma and Urinary Uric Acid Levels in Chinese Adults: An Interventional Trial.Scientific reports · 2018Trial
- Associations of Genetic Variants in Uric Acid Transporter Genes With Salt Sensitivity, Longitudinal Blood Pressure Changes, and Incident Hypertension in Chinese Adults.Journal of clinical hypertension (Greenwich, Conn.) · 2026Article
- A Comparison of Machine Learning Algorithms for Predicting Hypertension Incidence Based on Cohort Study.Endocrinology, diabetes & metabolism · 2026Article
- Therapeutic potential of traditional Chinese medicine for hyperuricemia: mechanistic insights and clinical prospects.Frontiers in pharmacology · 2026Review
- The role of uric acid in the risk of hypertension developed from prehypertension: a five-year Chinese urban cohort study.Archives of public health = Archives belges de sante publique · 2024Article
- Exploring the Relationship Between Different Obesity Metabolism Indices and Hyperuricemia in Patients with Hypertension and Coronary Heart Disease.Diabetes, metabolic syndrome and obesity : targets and therapy · 2024Article
- Plasma aldosterone concentrations elevation in hypertensive patients: the dual impact on hyperuricemia and gout.Frontiers in endocrinology · 2024Article
- Exploring the Effects of Elevated Serum Uric Acid Levels on Hypertension: A Scoping Review of Hyperuricemia.Cureus · 2023Article
- Article
- Serum Calprotectin Level as an Inflammatory Marker in Newly Diagnosed Hypertensive Patients.International journal of hypertension · 2022Article
- Hyperuricemia is independently associated with hypertension in men under 60 years in a general Chinese population.Journal of human hypertension · 2021Article
- Visit-to-visit variability of serum uric acid measurements and the risk of all-cause mortality in the general population.Arthritis research & therapy · 2021Article
- Sex Differences in Association of Elevated Blood Pressure with Variables Characterizing Cardiometabolic Risk in Young Subjects with or Without Metabolic Abnormalities.International journal of environmental research and public health · 2020Article
- Serum uric acid is associated with damage in patients with systemic lupus erythematosus.Lupus science & medicine · 2020Article
- Asymptomatic Hyperuricemia Associates with Cardiometabolic Risk Indicators in Overweight/Obese but Not in Lean Adolescents.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Higher baseline uric acid concentration is associated with non-attainment of optimal blood pressure.PloS one · 2020Article
- Association of uric acid in serum and urine with subclinical renal damage: Hanzhong Adolescent Hypertension Study.PloS one · 2019Observational
- Markers of endothelial injury and subclinical inflammation in children and adolescents with primary hypertension.Central-European journal of immunology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Uric acid is the end product of purine metabolism. Metabolic disorders of uric acid are associated with many disease states. Substantial evidence suggests the possible role of uric acid as a mediator of high blood pressure. Elevated uric acid is closely associated with new onset essential hypertension in adolescents and prehypertension; and urate-lowering agents can significantly improve these early stages of hypertension. Uric acid also influences salt sensitivity of blood pressure through two phases. Local renin-angiotensin-aldosterone system activation initiates renal damage, arteriolopathy, and endothelium dysfunction, which is followed by the dysregulation of sodium homeostasis, thereby leading to increased salt sensitivity. In this review we summarize the available evidence to contribute to a better understanding of the casual relationship between uric acid and early or intermediate stages of hypertension. We hope our review can contribute to the prevention of hypertension or provide new insights into a treatment that would slow the progression of hypertension.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.