Evidence map›Paper›PMID 28190711›Full record

ArticleImmunity2017

CD8

Anna Brewitz, Sarah Eickhoff, Sabrina Dähling, Thomas Quast, Sammy Bedoui, Richard A Kroczek, Christian Kurts, Natalio Garbi, Winfried Barchet, Matteo Iannacone and 6 more

Open access · bronzeAbstract read
In one paragraph

Article in Immunity, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 207 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
207citing papers in PubMed, 1 pooled it
14.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

207 citing papers in PubMed, 1 synthesis or guideline pooled it, 325 citations in OpenAlex.

  1. Pooled it
  2. Nutrients · 2024
    Trial
  3. Review
  4. Article
  5. Article
  6. Stem-like PD-1Journal for immunotherapy of cancer · 2026
    Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. Review
  12. Review
  13. Article
  14. Xcr1eLife · 2025
    Article
  15. Cytotoxic T Cells: Kill, Memorize, and Mask to Maintain Immune Homeostasis.International journal of molecular sciences · 2025
    Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Review

147 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 9 institutions in 5 countries.

Anna BrewitzInstitute of Experimental Immunology, University Hospital, University of Bonn, 53127 Bonn, Germany.
Sarah EickhoffInstitute of Experimental Immunology, University Hospital, University of Bonn, 53127 Bonn, Germany.
Sabrina DählingInstitute of Experimental Immunology, University Hospital, University of Bonn, 53127 Bonn, Germany.
Thomas QuastMolecular Immunology and Cell Biology, Life and Medical Sciences Institute, University of Bonn, 53115 Bonn, Germany.
Sammy BedouiDepartment of Microbiology and Immunology, The University of Melbourne, Peter Doherty Institute for Infection and Immunity, Parkville,VIC 3010, Australia.
Richard A KroczekMolecular Immunology, Robert-Koch-Institute, 13353 Berlin, Germany.
Christian KurtsInstitute of Experimental Immunology, University Hospital, University of Bonn, 53127 Bonn, Germany.
Natalio GarbiInstitute of Experimental Immunology, University Hospital, University of Bonn, 53127 Bonn, Germany.
Winfried BarchetInstitute of Clinical Chemistry and Clinical Pharmacology, University Hospital, University of Bonn, 53127 Bonn, Germany.
Matteo IannaconeDivision of Immunology, Transplantation and Infectious Diseases and Experimental Imaging Center, IRCCS San Raffaele Scientific Institute and Vita-Salute San Raffaele University, Via Olgettina 58, Milan 20132, Italy.
Frederick KlauschenInstitute of Pathology, Charité Universitätsmedizin Berlin, Charitéplatz 1, 10117 Berlin, Germany; Einstein Foundation Berlin, 10117 Berlin, Germany.
Waldemar KolanusMolecular Immunology and Cell Biology, Life and Medical Sciences Institute, University of Bonn, 53115 Bonn, Germany.
Tsuneyasu KaishoDepartment of Immunology, Institute of Advanced Medicine, Wakayama Medical University, Wakayama, Wakayama 641-8509, Japan; Laboratory for Inflammatory Regulation, RIKEN Center for Integrative Medical Sciences (IMS-RCAI), Yokohama, Kanagawa 230-0045, Japan; Laboratory for Immune Regulation, World Premier International Research Center Initiative, Immunology Frontier Research Center, Osaka University, Suita, Osaka 565-0871, Japan.
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63108, USA.
Ronald N GermainLymphocyte Biology Section, Laboratory of Systems Biology, National Institute of Allergy and Infectious Diseases, NIH, Bethesda, MD 20892-0421, USA.
Wolfgang KastenmüllerInstitute of Experimental Immunology, University Hospital, University of Bonn, 53127 Bonn, Germany. Electronic address: wkastenm@uni-bonn.de.
University of Bonn · DEUniversity Hospital Bonn · DEEinstein Foundation · DENational Institute of Allergy and Infectious Diseases · USRIKEN Center for Integrative Medical Sciences · JPRobert Koch Institute · DEUniversity of Melbourne · AUVita-Salute San Raffaele University · ITWashington University in St. Louis · US

Funding

Multiscale Analysis of Immune ResponsesZIAAI000545 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GERMAIN, RONALD N · 2009 to 2025
$29.4M
Functional Biology Of T CellsZIAAI000758 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI GERMAIN, RONALD N · 2009 to 2025
$15.4M
Intramural NIH HHS ZIA AI000545
6 · The paper itself

Abstract

Adaptive cellular immunity is initiated by antigen-specific interactions between T lymphocytes and dendritic cells (DCs). Plasmacytoid DCs (pDCs) support antiviral immunity by linking innate and adaptive immune responses. Here we examined pDC spatiotemporal dynamics during viral infection to uncover when, where, and how they exert their functions. We found that pDCs accumulated at sites of CD8

Indexed as

AnimalsCD8-Positive T-LymphocytesChemotaxis, LeukocyteCross-PrimingDendritic CellsEnzyme-Linked Immunosorbent AssayFlow CytometryFluorescent Antibody TechniqueMiceMice, TransgenicCCL3CCL4CCR5chemokinecooperationCXCR3migrationspatiotemporalviral infectionXCL1

Identifiers

PMID28190711
PMCPMC5362251
OpenAlexW2586317281

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.