ArticleNeuron2017
Divergent Hox Coding and Evasion of Retinoid Signaling Specifies Motor Neurons Innervating Digit Muscles.
Article in Neuron, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
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Who cites it
37 citing papers in PubMed.
- Spinal circuits encode a map of the trunk to control skin twitches.bioRxiv : the preprint server for biology · 2026Article
- Transcriptional and cellular maturation of the chick spinal cord in the context of distinct neuromuscular circuits.iScience · 2026Article
- Article
- Maternal thyroid hormone is required to develop the hindbrain vasculature in zebrafish.Communications biology · 2025Article
- Morphological segmentation with tiling light sheet microscopy to quantitatively analyze the three-dimensional structures of spinal motoneurons.Cell regeneration (London, England) · 2025Article
- HOX gene expression in the developing human spine.Nature communications · 2024Article
- Pre- and Postnatal Vitamin A Deficiency Impairs Motor Skills without a Consistent Effect on Trace Mineral Status in Young Mice.International journal of molecular sciences · 2024Article
- Spinal neuron diversity scales exponentially with swim-to-limb transformation during frog metamorphosis.bioRxiv : the preprint server for biology · 2024Article
- Review
- Identification and characterization of a potentially novel dorsal cutaneous muscle in rodents.bioRxiv : the preprint server for biology · 2024Article
- Efficient generation of lower induced motor neurons by coupling Ngn2 expression with developmental cues.Cell reports · 2023Article
- A method to investigate muscle target-specific transcriptional signatures of single motor neurons.Developmental dynamics : an official publication of the American Association of Anatomists · 2023Article
- Modular derivation of diverse, regionally discrete human posterior CNS neurons enables discovery of transcriptomic patterns.Science advances · 2022Article
- Transcriptional dynamics of murine motor neuron maturation in vivo and in vitro.Nature communications · 2022Article
- Singling out motor neurons in the age of single-cell transcriptomics.Trends in genetics : TIG · 2022Review
- Resting-state EEG reveals four subphenotypes of amyotrophic lateral sclerosis.Brain : a journal of neurology · 2022Article
- Article
- The histone demethylase Kdm6b regulates subtype diversification of mouse spinal motor neurons during development.Nature communications · 2022Article
- Article
- Establishing the Molecular and Functional Diversity of Spinal Motoneurons.Advances in neurobiology · 2022Article
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Authors and funding
3 authors.
Funding
Abstract
The establishment of spinal motor neuron subclass diversity is achieved through developmental programs that are aligned with the organization of muscle targets in the limb. The evolutionary emergence of digits represents a specialized adaptation of limb morphology, yet it remains unclear how the specification of digit-innervating motor neuron subtypes parallels the elaboration of digits. We show that digit-innervating motor neurons can be defined by selective gene markers and distinguished from other LMC neurons by the expression of a variant Hox gene repertoire and by the failure to express a key enzyme involved in retinoic acid synthesis. This divergent developmental program is sufficient to induce the specification of digit-innervating motor neurons, emphasizing the specialized status of digit control in the evolution of skilled motor behaviors. Our findings suggest that the emergence of digits in the limb is matched by distinct mechanisms for specifying motor neurons that innervate digit muscles.
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