Evidence map›Paper›PMID 28190219›Full record

ArticleVeterinary research communications2017

Temporal changes of microRNA gga-let-7b and gga-let-7i expression in chickens challenged with subgroup J avian leukosis virus.

Jun Ji, Huiqin Shang, Huanmin Zhang, Hongxin Li, Jingyun Ma, Yingzuo Bi, Qingmei Xie

Abstract read
PubMed Publisher
In one paragraph

Article in Veterinary research communications, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.4field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 23 citations in OpenAlex.

  1. MiRNAs in Poultry Health and Production: Progress and Challenges.Animals : an open access journal from MDPI · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jun JiChina-UK-NYNURRes Joint Laboratory of Insect Biology, Nanyang Normal University, Henan, 473061, People's Republic of China. jijun020@126.com.
Huiqin ShangBreeding and Reproduction, Ministry of Agriculture, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding and Key Lab of Chicken Genetics, Guangzhou, 510642, People's Republic of China.
Huanmin ZhangAgriculture Research Service, Avian Disease and Oncology Laboratory, USDA, East Lansing, MI, 48823, USA.
Hongxin LiBreeding and Reproduction, Ministry of Agriculture, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding and Key Lab of Chicken Genetics, Guangzhou, 510642, People's Republic of China.
Jingyun MaBreeding and Reproduction, Ministry of Agriculture, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding and Key Lab of Chicken Genetics, Guangzhou, 510642, People's Republic of China.
Yingzuo BiBreeding and Reproduction, Ministry of Agriculture, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding and Key Lab of Chicken Genetics, Guangzhou, 510642, People's Republic of China.
Qingmei XieBreeding and Reproduction, Ministry of Agriculture, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding and Key Lab of Chicken Genetics, Guangzhou, 510642, People's Republic of China. qmx@scau.edu.cn.
Key Laboratory of Guangdong Province · CNMichigan Department of Agriculture and Rural Development · USNanyang Normal University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Two important microRNAs, gga-let-7b and gga-let-7i were examined for the relative expression in liver and bone marrow tissues from specific pathogen free chickens that were challenged either with GD1109 or NX0101 strain of subgroup J avian leukosis virus (ALV-J). The GD1109 strain of ALV-J reportedly causes hemangioma (HE) and NX0101 reportedly causes myeloma (ML) in susceptible chickens. Temporal changes of both gga-let-7b and gga-let-7i expression in ALV-J infected chickens were observed in contrast to its counterpart of a non-infected negative control group of chickens (P < 0.05 or P < 0.01) during the first 120 days post infection. Use of the web-based computational DIANA-mirPath software (available at http://microrna.gr/mirpath ), it was predicted that both gga-let-7b and gga-let-7i were involved in multiple pathways including signaling pathways, such as MAPK, TGF-beta, Notch, Wnt, mTOR, Cell cycle, P53 and Jak-STAT. Combining our experimental data with reports on the microRNAs, we suggest that both gga-let-7i and gga-let-7b may also act as tumor suppressors in chicken, especially play a critical role in tumorigenesis induced by ALV-J.

Indexed as

Avian Leukosis VirusAnimalsAvian LeukosisChickensGene Expression Regulation, ViralMicroRNAsPolymerase Chain ReactionTime FactorsMicroRNAsALV-JGga-let-7b/7imicroRNATemporal expressionTumorigenesis

Identifiers

PMID28190219
OpenAlexW2587480354

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.