ArticleSleep & breathing = Schlaf & Atmung2017
Periodic limb movements in sleep are followed by increases in EEG activity, blood pressure, and heart rate during sleep.
Article in Sleep & breathing = Schlaf & Atmung, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 54 citations in OpenAlex.
- Socioeconomic status impacts blood pressure response to positive airway pressure treatment.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Trial
- A validation study of a ballistocardiograph sleep tracker against polysomnography.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Trial
- Nocturnal peripheral vasoconstriction predicts the frequency of severe acute pain episodes in children with sickle cell disease.American journal of hematology · 2021Trial
- Periodic limb movements of sleep and hypertension in patients with obstructive sleep apnea: a hypothesis-generating analysis from a polysomnographic cohort.Sleep & breathing = Schlaf & Atmung · 2026Article
- Article
- Autonomic characteristics of periodic limb movements: comparison of whole-night and stage N2 linear and non-linear heart rate variability.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2026Article
- Restless legs syndrome and periodic limb movements of sleep - the relationship with stroke and other cerebrovascular disease.Nature reviews. Neurology · 2026Review
- Acute effects of tonic motor activation (TOMAC) on sleep in adults with medication-refractory restless legs syndrome.Sleep advances : a journal of the Sleep Research Society · 2026Article
- Time-Dependent Autonomic Dysregulation and Co-Activation Induced by Periodic Limb Movements in Sleep.Journal of clinical medicine · 2025Article
- Relationship between gastroesophageal reflux disease and objective sleep quality.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2022Article
- Evaluating changes in pulse transit time drop index in patients with obstructive sleep apnea before and during CPAP therapy.The clinical respiratory journal · 2022Article
- A pilot study to understand the relationship between cortical arousals and leg movements during sleep.Scientific reports · 2022Article
- Periodic limb movements during sleep: a narrative review.Journal of thoracic disease · 2021Review
- Cognitive and Neuroimaging Correlates of the Insomnia Severity Index in Obstructive Sleep Apnea: A Pilot-Study.Applied sciences (Basel, Switzerland) · 2021Article
- Periodic Limb Movements Syndrome in Patients With Cerebral Small Vessel Disease: Protocol for a Prospective Observational Study.Frontiers in neurology · 2021Article
- Low Arousal Threshold: A Potential Bridge Between OSA and Periodic Limb Movements of Sleep.Nature and science of sleep · 2021Article
- Polysomnographic phenotyping of obstructive sleep apnea and its implications in mortality in Korea.Scientific reports · 2020Article
- Cardiometabolic comorbidities in obstructive sleep apnea patients are related to disease severity, nocturnal hypoxemia, and decreased sleep quality.Respiratory research · 2020Article
- Neurological Sleep Disorders and Blood Pressure: Current Evidence.Hypertension (Dallas, Tex. : 1979) · 2019Review
- Sleep disorders and the risk of stroke.Expert review of neurotherapeutics · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposePeriodic limb movements in sleep (PLMS) are related to arousal, sympathetic activation, and increases in blood pressure (BP), but whether they are part of the arousal process or causative of it is unclear. Our objective was to assess the temporal distribution of arousal-related measures around PLMS.
methodsPolysomnographic recordings of six patients with restless legs syndrome were analyzed. We analyzed 15 PLMS, plus three 5-s epochs before and after each movement, for every patient. Mean values per epoch of blood pressure (BP), heart rate (HR), and electroencephalographic (EEG) power were calculated. For each patient, six 5-s epochs of undisturbed sleep were analyzed as controls.
resultsAlpha + beta EEG power, systolic BP, and HR were significantly increased following PLMS. The EEG power and HR increases were noticed in the first epoch after PLMS, whereas that of systolic BP was observed in the second and third epochs following a PLMS. No significant changes occurred in the epochs of undisturbed sleep.
conclusionsThe results suggest that PLMS are followed by arousal-related nervous system events. Given the high frequency of PLMS throughout the night, they could be a potential risk factor for nocturnal arrhythmias and hypertension, in addition to causing sleep deprivation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.