Evidence map›Paper›PMID 28190084›Full record

ArticlePsychopharmacology2017

A comparison of psychotic symptoms in subjects with methamphetamine versus cocaine dependence.

Peter D Alexander, Kristina M Gicas, Taylor S Willi, Clara N Kim, Veronika Boyeva, Ric M Procyshyn, Geoff N Smith, Allen E Thornton, William J Panenka, Andrea A Jones and 5 more

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Psychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 3 pooled it
2.0field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 3 syntheses or guidelines pooled it, 27 citations in OpenAlex.

  1. Pooled it
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  4. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Peter D AlexanderDepartment of Pharmacology, 2176 Health Sciences Mall, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada.
Kristina M GicasDepartment of Psychology, Simon Fraser University, Burnaby, B.C., V5A 1S6, Canada.
Taylor S WilliDepartment of Psychology, Simon Fraser University, Burnaby, B.C., V5A 1S6, Canada.
Clara N KimDepartment of Pharmacology, 2176 Health Sciences Mall, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada.
Veronika BoyevaDepartment of Psychiatry, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada.
Ric M ProcyshynDepartment of Psychiatry, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada.
Geoff N SmithDepartment of Psychiatry, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada.
Allen E ThorntonDepartment of Psychology, Simon Fraser University, Burnaby, B.C., V5A 1S6, Canada.
William J PanenkaDepartment of Psychiatry, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada.
Andrea A JonesDepartment of Psychiatry, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada.
Fidel Vila-RodriguezDepartment of Psychiatry, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada.
Donna J LangDepartment of Radiology, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada.
G William MacEwanDepartment of Psychiatry, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada.
William G HonerDepartment of Psychiatry, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada.
Alasdair M BarrDepartment of Pharmacology, 2176 Health Sciences Mall, University of British Columbia, Vancouver, B.C., V6T 1Z3, Canada. al.barr@ubc.ca.
University of British Columbia · CASimon Fraser University · CA

Funding

CIHR CBG-101827CIHR MOP-137103
6 · The paper itself

Abstract

rationaleThe psychostimulant drugs cocaine and methamphetamine are potent indirect dopamine receptor agonists which act through similar but not identical mechanisms. Studies in humans have observed that a large proportion of those who chronically use these drugs experience psychotic symptoms. However, direct comparisons of psychotic symptom severity between cocaine and methamphetamine users are lacking.

objectivesThe goal of the present study was to directly compare severity of psychotic symptoms between cocaine- and methamphetamine-dependent individuals. Additionally, we sought to determine how concurrent cocaine + methamphetamine dependence would influence psychotic symptoms.

methodsWe recruited 153 polysubstance-using subjects meeting DSM-IV-TR criteria for cocaine dependence, 38 with methamphetamine dependence, and 32 with cocaine + methamphetamine dependence. Psychotic symptoms were assessed with the Positive and Negative Syndrome Scale (PANSS) and analyzed using a five-factor model. All participants were also assessed for physical and mental illnesses as well as recent substance use. Most subjects completed a comprehensive neurocognitive battery.

resultsWhile all three groups exhibited high total PANSS scores, the positive symptom subscale was significantly higher in the methamphetamine-dependent (17.03 ± 6.3) than the cocaine-dependent group (13.51 ± 4.12) and non-significantly higher (p = 0.08) than the cocaine + methamphetamine group (14.44 ± 5.50). Groups also differed on demographic variables, viral infection, and other indices of substance use, which were unlikely to account for the difference in positive symptoms. There were only modest differences between groups in neurocognitive function.

conclusionsMethamphetamine dependence was associated with more severe positive symptoms of psychosis than cocaine dependence. Concurrent cocaine + methamphetamine dependence did not increase psychosis severity.

Indexed as

MethamphetamineAdultAmphetamine-Related DisordersCentral Nervous System StimulantsCocaine-Related DisordersCohort StudiesDiagnostic and Statistical Manual of Mental DisordersFemaleFollow-Up StudiesHumansMaleMiddle AgedPsychoses, Substance-InducedCentral Nervous System StimulantsMethamphetamineCocaineDependenceMethamphetamineNeurocognitionPANSSPsychosisPsychostimulantSubstance useSymptom severity

Identifiers

PMID28190084
OpenAlexW2587097985

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.