Evidence map›Paper›PMID 28190002›Full record

ArticleThe Journal of biological chemistry2017

Cytochrome P450 27A1 Deficiency and Regional Differences in Brain Sterol Metabolism Cause Preferential Cholestanol Accumulation in the Cerebellum.

Natalia Mast, Kyle W Anderson, Joseph B Lin, Yong Li, Illarion V Turko, Curtis Tatsuoka, Ingemar Bjorkhem, Irina A Pikuleva

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
3.5field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 33 citations in OpenAlex.

  1. Cholestanol promotes tau pathology in a mouse model of tauopathy.Cellular and molecular life sciences : CMLS · 2025
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  15. Localization of sterols and oxysterols in mouse brain reveals distinct spatial cholesterol metabolism.Proceedings of the National Academy of Sciences of the United States of America · 2020
    Article
  16. Article
  17. Article
  18. Sterolomics in biology, biochemistry, medicine.Trends in analytical chemistry : TRAC · 2019
    Review
  19. Additional pathways of sterol metabolism: Evidence from analysis of Cyp27a1-/- mouse brain and plasma.Biochimica et biophysica acta. Molecular and cell biology of lipids · 2019
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Natalia MastFrom the Departments of Ophthalmology and Visual Sciences and.
Kyle W Andersonthe Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899.
Joseph B LinFrom the Departments of Ophthalmology and Visual Sciences and.
Yong LiFrom the Departments of Ophthalmology and Visual Sciences and.
Illarion V Turkothe Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, Maryland 20899.
Curtis TatsuokaNeurology, Case Western Reserve University, Cleveland, Ohio 44106.
Ingemar Bjorkhemthe Division of Clinical Chemistry, Department of Laboratory Medicine, Karolinska Institute, 141 86 Huddinge, Sweden.
Irina A PikulevaFrom the Departments of Ophthalmology and Visual Sciences and iap8@case.edu.
Case Western Reserve University · USInstitute for Bioscience and Biotechnology ResearchKarolinska Institutet · SENational Institute of Standards and Technology · US

Funding

TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7M
Structure and function of cholesterol metabolizing P450sR01GM062882 · NIGMS · UNIVERSITY OF TEXAS MEDICAL BR GALVESTON · PI PIKULEVA, IRINA A · 2001 to 2019
$5.5M
NEI NIH HHS P30 EY011373NIGMS NIH HHS R01 GM062882
6 · The paper itself

Abstract

Cytochrome P450 27A1 (CYP27A1 or sterol 27-hydroxylase) is a ubiquitous, multifunctional enzyme catalyzing regio- and stereospecific hydroxylation of different sterols. In humans, complete CYP27A1 deficiency leads to cerebrotendinous xanthomatosis or nodule formation in tendons and brain (preferentially in the cerebellum) rich in cholesterol and cholestanol, the 5α-saturated analog of cholesterol. In

Indexed as

AnimalsBrainCerebellumCholestanetriol 26-MonooxygenaseCholestanolCholestenonesCholesterolCholesterol 24-HydroxylaseFemaleGene Knockout TechniquesHumansMaleMiceMice, Inbred C57BLMice, Knockout7 alpha-hydroxy-4-cholesten-3-oneCholestanetriol 26-MonooxygenaseCholestanolCholestenonesCholesterolCholesterol 24-HydroxylaseCYP27A1 protein, humanCyp27a1 protein, mousebraincerebellumcholesterolcholesterol metabolismcholesterol regulationcytochrome P450

Identifiers

PMID28190002
PMCPMC5377805
OpenAlexW2587026642

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.