Evidence map›Paper›PMID 28189801›Full record

ArticleBone2017

Osteoblast-derived FGF9 regulates skeletal homeostasis.

Liping Wang, Theresa Roth, Marcia Abbott, Linh Ho, Lalita Wattanachanya, Robert A Nissenson

Open access · greenAbstract read
In one paragraph

Article in Bone, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 31 citations in OpenAlex.

  1. FGF family in health and disease.Molecular biomedicine · 2026
    Review
  2. Article
  3. Review
  4. Article
  5. A Functional Regulatory Variant ofAnimals : an open access journal from MDPI · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Review
  10. Article
  11. International journal of biological sciences · 2024
    Article
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  13. Review
  14. Article
  15. Review
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Liping WangEndocrine Unit, VA Medical Center, San Francisco, CA, USA; Department of Medicine, University of California, San Francisco, CA, USA.
Theresa RothEndocrine Unit, VA Medical Center, San Francisco, CA, USA.
Marcia AbbottEndocrine Unit, VA Medical Center, San Francisco, CA, USA.
Linh HoEndocrine Unit, VA Medical Center, San Francisco, CA, USA.
Lalita WattanachanyaEndocrine Unit, VA Medical Center, San Francisco, CA, USA; Division of Endocrinology and Metabolism, Department of Medicine, Faculty of Medicine, Chulalongkorn University, Thai Red Cross Society, Bangkok, Thailand; King Chulalongkorn Memorial Hospital, Bangkok, Thailand.
Robert A NissensonEndocrine Unit, VA Medical Center, San Francisco, CA, USA; Department of Medicine, University of California, San Francisco, CA, USA. Electronic address: Robert.Nissenson@ucsf.edu.
San Francisco VA Medical Center · USThai Red Cross Society · TH

Funding

UCSF Core Center for Musculoskeletal Biology and MedicineP30AR066262 · NIAMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI LOTZ, JEFFREY C. · 2014 to 2018
$3.0M
BLRD VA I01 BX001496BLRD VA I01 BX003212NIAMS NIH HHS P30 AR066262
6 · The paper itself

Abstract

FGF9 has complex and important roles in skeletal development and repair. We have previously observed that Fgf9 expression in osteoblasts (OBs) is regulated by G protein signaling and therefore the present study was done to determine whether OB-derived FGF9 was important in skeletal homeostasis. To directly test this idea, we deleted functional expression of Fgf9 gene in OBs using a 2.3kb collagen type I promoter-driven Cre transgenic mouse line (Fgf9

Indexed as

AnimalsBone and BonesCell DifferentiationFemaleFibroblast Growth Factor 9HomeostasisImmunoblottingMaleMiceMice, KnockoutMice, TransgenicOsteoblastsOsteogenesisPolymerase Chain ReactionX-Ray MicrotomographyFgf9 protein, mouseFibroblast Growth Factor 9AktBone formationFGF9OsteoblastsStem cells

Identifiers

PMID28189801
PMCPMC8474898
OpenAlexW2587204882

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.