ArticleNeuroImage2017
Dissociable frontostriatal white matter connectivity underlies reward and motor impulsivity.
Article in NeuroImage, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Lateralization of self-control over the dorsolateral prefrontal cortex in decision-making: a systematic review and meta-analytic evidence from noninvasive brain stimulation.Cognitive, affective & behavioral neuroscience · 2024Pooled it
- Non-invasive stimulation of the human striatum disrupts reinforcement learning of motor skills.Nature human behaviour · 2024Trial
- Alcohol effects on globus pallidus connectivity: Role of impulsivity and binge drinking.PloS one · 2020Trial
- Thalamo-cortical white matter connectivity-defined thalamic subarea volumes predict individual delay discounting.Molecular psychiatry · 2026Article
- Diffusion connectometry reveals white matter substrates of individual differences in loss aversion.Scientific reports · 2025Article
- Frontostriatal Networks Undergo Functional Specialization during Adolescence That Follows a Ventral-Dorsal Gradient: Developmental Trajectories and Longitudinal Associations.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Effects of a 5-HTScientific reports · 2024Article
- Connection Failure: Differences in White Matter Microstructure Are Associated withInternational journal of molecular sciences · 2024Article
- Disentangling the neurobiological bases of temporal impulsivity in Huntington's disease.Brain and behavior · 2024Article
- Structural projections to the nucleus accumbens link to impulsive components of human risk preference.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- White matter-based brain network topological properties associated with individual impulsivity.Scientific reports · 2023Article
- Selective chemogenetic inactivation of corticoaccumbal projections disrupts trait choice impulsivity.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- Sex differences in atypical fronto-subcortical structural connectivity among children with attention-deficit/hyperactivity disorder: Associations with delay discounting.Behavioural brain research · 2023Article
- Investigating associations of delay discounting with brain structure, working memory, and episodic memory.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- The right inferior frontal gyrus as pivotal node and effective regulator of the basal ganglia-thalamocortical response inhibition circuit.Psychoradiology · 2023Article
- Brain tract structure predicts relapse to stimulant drug use.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Impulsive trait mediates the relationship between white matter integrity of prefrontal-striatal circuits and the severity of dependence in alcoholism.Frontiers in psychiatry · 2022Article
- Chemogenetic inactivation reveals the inhibitory control function of the prefronto-striatal pathway in the macaque brain.Communications biology · 2021Article
- Brain multimodal co-alterations related to delay discounting: a multimodal MRI fusion analysis in persons with and without cocaine use disorder.BMC neuroscience · 2021Article
- Dopamine-related striatal neurophysiology is associated with specialization of frontostriatal reward circuitry through adolescence.Progress in neurobiology · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Dysfunction of cognitive control often leads to impulsive decision-making in clinical and healthy populations. Some research suggests that a generalized cognitive control mechanism underlies the ability to modulate various types of impulsive behavior, while other evidence suggests different forms of impulsivity are dissociable, and rely on distinct neural circuitry. Past research consistently implicates several brain regions, such as the striatum and portions of the prefrontal cortex, in impulsive behavior. However the ventral and dorsal striatum are distinct in regards to function and connectivity. Nascent evidence points to the importance of frontostriatal white matter connectivity in impulsivity, yet it remains unclear whether particular tracts relate to different control behaviors. Here we used probabilistic tractography of diffusion imaging data to relate ventral and dorsal frontostriatal connectivity to reward and motor impulsivity measures. We found a double dissociation such that individual differences in white matter connectivity between the ventral striatum and the ventromedial prefrontal cortex and dorsolateral prefrontal cortex was associated with reward impulsivity, as measured by delay discounting, whereas connectivity between dorsal striatum and supplementary motor area was associated with motor impulsivity, but not vice versa. Our findings suggest that (a) structural connectivity can is associated with a large amount of behavioral variation; (b) different types of impulsivity are driven by dissociable frontostriatal neural circuitry.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.