Evidence map›Paper›PMID 28189352›Full record

ArticleBurns : journal of the International Society for Burn Injuries2017

Burn mortality in patients with preexisting cardiovascular disease.

Laquanda Knowlin, Trista Reid, Felicia Williams, Bruce Cairns, Anthony Charles

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Burns : journal of the International Society for Burn Injuries, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07526610 (Predictive Mortality Scales in the Burn Patient Admitted to the Intensive Care Unit), which is not on this map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07526610 completednot on this mapstarted 2019, after this paper: background citation

Predictive Mortality Scales in the Burn Patient Admitted to the Intensive Care Unit

TypeobservationalSponsorUniversidad Rey Juan CarlosRan2019 to 2026Enrolled465ConditionsBurn Any Degree Involving 20-29 Percent of Body Surface, Burn Any Degree Involving 30-39 Percent of Body Surface, Burn Any Degree Involving 40-49 Percent of Body Surface, Burn Any Degree Involving 50-59 Percent of Body Surface
3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Laquanda KnowlinDepartment of Surgery, University of North Carolina at Chapel Hill, North Carolina Jaycee Burn Center, United States.
Trista ReidDepartment of Surgery, University of North Carolina at Chapel Hill, North Carolina Jaycee Burn Center, United States.
Felicia WilliamsDepartment of Surgery, University of North Carolina at Chapel Hill, North Carolina Jaycee Burn Center, United States.
Bruce CairnsDepartment of Surgery, University of North Carolina at Chapel Hill, North Carolina Jaycee Burn Center, United States.
Anthony CharlesDepartment of Surgery, University of North Carolina at Chapel Hill, North Carolina Jaycee Burn Center, United States. Electronic address: anthchar@med.unc.edu.
University of North Carolina at Chapel Hill · US

Funding

TRAUMA RESEARCH FELLOWSHIPT32GM008450 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI Bruce A Cairns, Anthony G Charles · 1992 to 2026
$3.8M
NIGMS NIH HHS T32 GM008450
6 · The paper itself

Abstract

introductionBurn shock, a complex process, which develops following burn leads to severe and unique derangement of cardiovascular function. Patients with preexisting comorbidities such as cardiovascular diseases may be more susceptible. We therefore sought to examine the impact of preexisting cardiovascular disease on burn outcomes.

methodsA retrospective analysis of patients admitted to a regional burn center from 2002 to 2012. Independent variables analyzed included basic demographics, burn mechanism, presence of inhalation injury, TBSA, pre-existing comorbidities, and length of ICU/hospital stay. Bivariate analysis was performed and Poisson regression modeling was utilized to estimate the incidence of being in the ICU and mortality.

resultsThere were a total of 5332 adult patients admitted over the study period. 6% (n=428) had a preexisting cardiovascular disease. Cardiovascular disease patients had a higher mortality rate (16%) compared to those without cardiovascular disease (3%, p<0.001). The adjusted Poisson regression model to estimate incidence risk of being in intensive care unit in patients with cardiovascular disease was 33% higher compared to those without cardiovascular disease (IRR=1.33, 95% CI=1.22-1.47). The risk for mortality is 42% higher (IRR=1.42, 95% CI=1.10-1.84) for patients with pre-existing cardiovascular disease compared to those without cardiovascular disease after controlling for other covariates.

conclusionPreexisting cardiovascular disease significantly increases the risk of intensive care unit admission and mortality in burn patients. Given the increasing number of Americans with cardiovascular diseases, there will likely be a greater number of individuals at risk for worse outcomes following burn. This knowledge can help with burn prognostication.

Indexed as

AdolescentAdultBurnsBurn UnitsCardiovascular DiseasesChildFemaleHumansLength of StayMaleMiddle AgedMultivariate AnalysisPrognosisRetrospective StudiesRisk FactorsShockBurnBurn mortalityBurn prognosticationCardiovascular diseaseComorbidities

Identifiers

PMID28189352
PMCPMC5912170
OpenAlexW2586756210

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.