Trial reportBiochimica et biophysica acta. Molecular basis of disease2017
Metabolomic profiling of lung function in Costa-Rican children with asthma.
Trial report in Biochimica et biophysica acta. Molecular basis of disease, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
42 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Metabolite signatures associated with microRNA miR-143-3p serve as drivers of poor lung function trajectories in childhood asthma.EBioMedicine · 2024Pooled it
- Transcriptome-wide association study of circulating IgE levels identifies novel targets for asthma and allergic diseases.Frontiers in immunology · 2023Pooled it
- Association between nasal airway metabolome signatures and lung function at age 6 years among children with post-bronchiolitis asthma.ERJ open research · 2026Article
- Differences in microRNA levels across metabo-endotypes reveal novel insights into asthma heterogeneity.Respiratory research · 2026Article
- Review
- MiR-107 and Its Association With House Dust Mite Sensitisation: Implications for Asthma.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2025Article
- Immunomodulatory metabolites in IgE-mediated food allergy and oral immunotherapy outcomes based on metabolomic profiling.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2024Article
- Urine metabolomics signature reveals novel determinants of adrenal suppression in children taking inhaled corticosteroids to control asthma symptoms.Immunity, inflammation and disease · 2024Article
- Deciphering the Interplay between the Epithelial Barrier, Immune Cells, and Metabolic Mediators in Allergic Disease.International journal of molecular sciences · 2024Review
- Consistent Multi-Omic Relationships Uncover Molecular Basis of Pediatric Asthma IgE Regulation.medRxiv : the preprint server for health sciences · 2024Article
- Serum Metabolomics Reveals Metabolomic Profile and Potential Biomarkers in Asthma.Allergy, asthma & immunology research · 2024Article
- Exploring Biomarkers in Asthma: Insights From Serum Metabolomics.Allergy, asthma & immunology research · 2024Article
- Age-specific Metabolomic profiles in children with food allergy.Clinical immunology (Orlando, Fla.) · 2024Article
- Metabolomics in Animal Models of Bronchial Asthma and Its Translational Importance for Clinics.International journal of molecular sciences · 2023Review
- Article
- Metabolomics of Respiratory Diseases.Handbook of experimental pharmacology · 2023Review
- Air pollution, metabolites and respiratory health across the life-course.European respiratory review : an official journal of the European Respiratory Society · 2022Review
- Urinary metabotype of severe asthma evidences decreased carnitine metabolism independent of oral corticosteroid treatment in the U-BIOPRED study.The European respiratory journal · 2022Article
- Metabolomics in asthma: A platform for discovery.Molecular aspects of medicine · 2022Review
- Metabolomic Associations of Asthma in the Hispanic Community Health Study/Study of Latinos.Metabolites · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
backgroundThe development of novel therapeutics and treatment regimens for the management of asthma is hindered by an incomplete understanding of its heterogeneous nature and pathophysiology. Metabolomics can provide an integrated and global profile of a biological system in a dysregulated state, making it a valuable tool to identify biomarkers along the disease development pathway and to understand the biological mechanisms driving that pathway.
methodsLiquid chromatography-mass spectrometry metabolomic profiling was conducted on plasma samples provided at recruitment for 380 children with asthma from the 'Genetic Epidemiology of Asthma in Costa Rica Cohort'. Metabolites associated with three clinical characteristics of asthma severity (i) airway hyper-responsiveness (AHR) (ii) percent-predicted forced expiratory volume in one second/forced vital capacity ratio (FEV
resultsAHR was associated (p<0.05) with 91 of 574 metabolites (15.9%), FEV
conclusionsThe results confirm the existence of an asthma severity metabolome. However, differences in the metabolomic profiles of the three lung function characteristics studied, suggest that refinement of both phenotype classification and metabolite selection should be a priority as the field of asthma metabolomics progresses.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.