ArticleGastroenterology2017
High Incidence of Celiac Disease in a Long-term Study of Adolescents With Susceptibility Genotypes.
Article in Gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 94 citations in OpenAlex.
- Examination of eating attitudes and symptoms of orthorexia nervosa in adolescents with and without celiac disease.Journal of eating disorders · 2025Article
- Development and Validation of a Pediatric Celiac Disease-Specific Quality of Life Measure.The American journal of gastroenterology · 2025Article
- Clinical settings in which human leukocyte antigen typing is still useful in the diagnosis of celiac disease.World journal of gastroenterology · 2025Review
- Applicability of ESPGHAN Biopsy-Free Guidelines for Celiac Disease Diagnosis: Insights from Türkiye.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2025Article
- Children who develop celiac disease are predicted to exhibit distinct metabolic pathways among their gut microbiota years before diagnosis.Microbiology spectrum · 2025Article
- Celiac disease screening in children: evaluating the evidence, benefits, and challenges.Frontiers in pediatrics · 2025Review
- Review
- Recent Trends in Seroprevalence of Celiac Disease at a Tertiary Care Center.Journal of pharmacy & bioallied sciences · 2024Article
- Coeliac disease: what can we learn from prospective studies about disease risk?The Lancet. Child & adolescent health · 2024Review
- Population-Based Screening for Coeliac Disease in Lithuanian Children from 2009 to 2014.Medicina (Kaunas, Lithuania) · 2023Article
- Endometriosis and Adolescence: The Impact of Dysmenorrhea.Journal of clinical medicine · 2023Review
- Dynamics of the gut microbiome, IgA response, and plasma metabolome in the development of pediatric celiac disease.Microbiome · 2023Article
- The Frequency of Undiagnosed Celiac Disease in Youth with Type 1 Diabetes and Its Association with Diabetic Retinopathy: The SEARCH for Diabetes in Youth Study.Pediatric diabetes · 2023Article
- Intervention strategies in early childhood to prevent celiac disease-a mini-review.Frontiers in immunology · 2023Review
- Review
- Knowledge regarding celiac disease among healthcare professionals, patients and their caregivers in Turkey.World journal of gastrointestinal pathophysiology · 2022Article
- Sources of dietary gluten in the first 2 years of life and associations with celiac disease autoimmunity and celiac disease in Swedish genetically predisposed children: The Environmental Determinants of Diabetes in the Young (TEDDY) study.The American journal of clinical nutrition · 2022Article
- Family ties: the impact of celiac disease on children and caregivers.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2022Article
- Epidemiology of Disorders Associated with Short Stature in Childhood: A 20-Year Birth Cohort Study in Finland.Clinical epidemiology · 2022Article
- Autoimmune Diseases of Digestive Organs-A Multidisciplinary Challenge: A Focus on Hepatopancreatobiliary Manifestation.Journal of clinical medicine · 2021Review
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
Abstract
BACKGROUND &
aimsLittle is known about the incidence of celiac disease in the general population of children in the United States. We aimed to estimate the cumulative incidence of celiac disease in adolescents born in the Denver metropolitan area.
methodsWe collected data on HLA-DR, DQ genotypes of 31,766 infants, born from 1993 through 2004 at St. Joseph's Hospital in Denver, from the Diabetes Autoimmunity Study in the Young. Subjects with susceptibility genotypes for celiac disease and type 1 diabetes were followed up for up to 20 years for development of tissue transglutaminase autoantibodies (tTGA). Outcomes were the development of celiac disease autoimmunity (CDA) or celiac disease. CDA was defined as persistence of tTGA for at least 3 months or development of celiac disease. Celiac disease was defined based on detection of Marsh 2 or greater lesions in biopsy specimens or persistent high levels of tTGA. For each genotype, the cumulative incidence of CDA and celiac disease were determined. To estimate the cumulative incidence in the Denver general population, outcomes by each genotype were weighted according to the frequency of each of these genotypes in the general population.
resultsOf 1339 subjects followed up, 66 developed CDA and met criteria for celiac disease and 46 developed only CDA. Seropositivity for tTGA resolved spontaneously, without treatment, in 21 of the 46 subjects with only CDA (46%). The estimated cumulative incidence for CDA in the Denver general population at 5, 10, and 15 years of age was 2.4%, 4.3%, and 5.1%, respectively, and incidence values for celiac disease were 1.6%, 2.8%, and 3.1%, respectively.
conclusionsIn a 20-year prospective study of 1339 children with genetic risk factors for celiac disease, we found the cumulative incidence of CDA and celiac disease to be high within the first 10 years. Although more than 5% of children may experience a period of CDA, not all children develop celiac disease or require gluten-free diets.
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