ArticleInternational journal of bipolar disorders2017
Poor quality of life and functioning in bipolar disorder.
Article in International journal of bipolar disorders, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01331304 (Comparative Effectiveness of a Second Generation Antipsychotic Mood Stabilizer And a Classic Mood Stabilizer for Bipolar Disorder), which is not on this map. Cited by 34 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Comparative Effectiveness of a Second Generation Antipsychotic Mood Stabilizer And a Classic Mood Stabilizer for Bipolar Disorder
Who cites it
34 citing papers in PubMed, 100 citations in OpenAlex.
- Home-based transcranial direct current stimulation (tDCS) for bipolar depression: effects on quality of life and functioning-an open-label study.Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation · 2026Trial
- Exploring factors associated with personal recovery in bipolar disorder.Psychology and psychotherapy · 2021Trial
- From Early Adversity to Adult Health: Quality-of-Life Consequences in A Mental Illness in Saudi Arabia.Saudi medical journal · 2026Article
- A feasibility study of two variants of a blended functional remediation programme for euthymic patients with bipolar I disorder.The British journal of clinical psychology · 2026Article
- Validity and reliability of the Japanese Adult Social Care Outcomes Toolkit four-level Self Completion Tool (ASCOT SCT4) in community mental health service users in Japan.Health and quality of life outcomes · 2026Article
- Article
- Discrete early maladaptive schema subgroups in remitted bipolar disorders: association with neuropsychological performance, residual symptoms, and psychosocial functioning.Frontiers in psychology · 2025Article
- Cognitive abilities and psychosocial functioning in bipolar disorder: findings from the BIPLONG study.Frontiers in human neuroscience · 2025Article
- Depressive disorder, bipolar disorder, and associated factors among adults, in the Eastern part of Ethiopia.BMC psychiatry · 2024Article
- Article
- Enhancing work life through social cognition: the effect of SCIT in bipolar disorder.Frontiers in psychology · 2024Article
- Quality of Life and Functioning Impairments Across Psychiatric Disorders in Adults Presenting for Outpatient Psychiatric Evaluation and Treatment.Psychiatric research and clinical practice · 2024Article
- Comparative Analysis of Personality Traits in Major Depressive Disorder and Bipolar Disorder: Impact, Differences, and Associations with Symptoms.Neuropsychiatric disease and treatment · 2024Article
- Profiles of quality of life among patients using emergency departments for mental health reasons.Health and quality of life outcomes · 2023Article
- Predominant polarity in bipolar affective disorder and its impact on cognition and quality of life.Indian journal of psychiatry · 2023Article
- Association between the epigenetic lifespan predictor GrimAge and history of suicide attempt in bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Article
- The Relationship between Predominant Polarity, Lifetime Comorbid Anxiety Disorders and Subjective Quality of Life among Individuals with Bipolar Disorder in Singapore.International journal of environmental research and public health · 2023Article
- Opportunities for digital health technology: identifying unmet needs for bipolar misdiagnosis and depression care management.Frontiers in digital health · 2023Article
- Prioritizing Treatment Goals of People Diagnosed with Bipolar I Disorder in the US: Best-Worst Scaling Results.Patient preference and adherence · 2023Article
- Review
Corrections and comments
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Authors and funding
17 authors at 13 institutions in 1 country.
Funding
Abstract
backgroundThis study explores the association of demographic and clinical features with quality of life and functioning in individuals with bipolar disorder.
methodsAdult participants (N = 482) with bipolar I or II disorder were enrolled in a comparative effectiveness study across eleven study sites and completed baseline measures of medical and psychiatric history, current mood, quality of life, and functioning. Participants with at least mildly depressive or manic/hypomanic symptomatic severity were randomized to receive lithium or quetiapine in addition to adjunctive personalized treatment for 6 months.
resultsParticipants with more severe depressive and irritability symptoms had lower quality of life and higher functional impairment. All psychiatric comorbid conditions except substance use disorder were associated with worse quality of life. On average, females had lower quality of life than males. Patients who were married, living as married, divorced, or separated had worse functional impairment compared with patients who were single or never married. A composite score of social disadvantage was associated with worse functioning and marginally associated with worse quality of life. Symptom severity did not moderate the effect of social disadvantage on quality of life or functioning.
conclusionsOur findings highlight that depression, irritability, and psychiatric comorbid conditions negatively impact quality of life and functioning in bipolar disorder. The study suggests that individuals with social disadvantage are at risk for functional impairment. Trial Registration This study is registered with ClinicalTrials.gov. Identification number: NCT01331304.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.