Evidence map›Paper›PMID 28188479›Full record

ArticleEndocrine2017

Short-term UVB irradiation significantly increases vitamin D serum concentration in obese patients: a clinical pilot study.

Alexander Obbarius, Heike Berger, Andreas Stengel, Carmen Garcia, Felix Fischer, Tobias Hofmann, Matthias Rose, Ralf Uebelhack

Abstract readControlled Clinical Trial
PubMed Publisher
In one paragraph

Article in Endocrine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Alexander ObbariusCenter for Internal Medicine and Dermatology, Department of Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, Charitéplatz 1, Berlin, 10117, Germany. alexander.obbarius@charite.de.
Heike BergerCenter for Internal Medicine and Dermatology, Department of Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, Charitéplatz 1, Berlin, 10117, Germany.
Andreas StengelCenter for Internal Medicine and Dermatology, Department of Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, Charitéplatz 1, Berlin, 10117, Germany.
Carmen GarciaSleep Medicine Center, Charité-Universitätsmedizin Berlin, Charitéplatz 1, Berlin, 10117, Germany.
Felix FischerCenter for Internal Medicine and Dermatology, Department of Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, Charitéplatz 1, Berlin, 10117, Germany.
Tobias HofmannCenter for Internal Medicine and Dermatology, Department of Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, Charitéplatz 1, Berlin, 10117, Germany.
Matthias RoseCenter for Internal Medicine and Dermatology, Department of Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, Charitéplatz 1, Berlin, 10117, Germany.
Ralf UebelhackMedical Photobiology Group, Charité-Universitätsmedizin Berlin, Charitéplatz 1, Berlin, 10117, Germany.
Charité - Universitätsmedizin Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeDeficiency of vitamin D is very common in obese people and treatment by oral supplementation is not effective in all patients. This exploratory pilot study investigated the influence of different doses of short-term ultraviolet B irradiation on serum 25-hydroxyvitamin-D

methodsParticipants with skin types II and III (Fitzpatrick skin classification) were assigned to six groups including four intervention groups receiving irradiation (three groups of obese and one group of normal weight subjects) and two control groups without treatment (obese and normal weight). Intervention groups received three sessions of whole body UVB irradiation of three different doses (cumulative doses over three sessions: 0.28, 0.70, 1.75 minimal erythema dose) within 1 week of intervention. Serum 25D and 1,25D were measured at baseline and after irradiation. Outcome differences between groups were analyzed using a linear model.

resultsSerum 25D levels increased significantly in obese (+23.6 and +26.7%, respectively, p = 0.01) and normal weight (+15.6%, p = 0.02) intervention groups who received medium and high doses of ultraviolet B irradiation compared to control groups (+3.5 and -4.0%, respectively, p = 1.0). The increase in obese patients was 51.4% greater compared to normal weight controls irradiated with equal ultraviolet B doses. Low-level ultraviolet irradiation did not result in a significant change in serum 25D (+7.0%, p = 0.61). We did not detect any significant differences of 1,25D between groups (p = 0.25).

conclusionsThe current study indicates that short-term ultraviolet B irradiation increases 25D levels in obese patients.

Indexed as

AdultCalcifediolFemaleHumansMaleMiddle AgedObesityPilot ProjectsUltraviolet RaysUltraviolet TherapyVitamin DVitamin D DeficiencyCalcifedioldihydroxy-vitamin D3Vitamin D1,25-Dihydroxyvitamin-D325-Hydroxyvitamin-D3Non-randomized controlled clinical trialObesityUVB irradiationVitamin D

Identifiers

PMID28188479
OpenAlexW2586608648

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.