Evidence map›Paper›PMID 28188441›Full record

ArticleVirchows Archiv : an international journal of pathology2017

Factors that may influence polymorphous low-grade adenocarcinoma growth.

Andresa Borges Soares, Elizabeth Ferreira Martinez, Patricia Fernandes Avila Ribeiro, Icleia Siqueira Barreto, Maria Cássia Aguiar, Cristiane Furuse, Marcelo Sperandio, Victor Angelo Montalli, Ney Soares de Araújo, Vera Cavalcanti de Araújo

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In one paragraph

Article in Virchows Archiv : an international journal of pathology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Polymorphous adenocarcinoma of the salivary glands: reappraisal and update.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Andresa Borges SoaresDepartment of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira, 13 Ponte Preta, Campinas, SP, 13045-755, Brazil. andresabs@hotmail.com.
Elizabeth Ferreira MartinezDepartment of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira, 13 Ponte Preta, Campinas, SP, 13045-755, Brazil.
Patricia Fernandes Avila RibeiroDepartment of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira, 13 Ponte Preta, Campinas, SP, 13045-755, Brazil.
Icleia Siqueira BarretoDepartment of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira, 13 Ponte Preta, Campinas, SP, 13045-755, Brazil.
Maria Cássia AguiarDepartment of Oral Pathology, Federal University of Minas Gerais, Belo Horizonte, MG, Brazil.
Cristiane FuruseDepartment of Oral Pathology, State University of São Paulo, Araçatuba, SP, Brazil.
Marcelo SperandioDepartment of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira, 13 Ponte Preta, Campinas, SP, 13045-755, Brazil.
Victor Angelo MontalliDepartment of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira, 13 Ponte Preta, Campinas, SP, 13045-755, Brazil.
Ney Soares de AraújoDepartment of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira, 13 Ponte Preta, Campinas, SP, 13045-755, Brazil.
Vera Cavalcanti de AraújoDepartment of Oral Pathology, São Leopoldo Mandic Institute and Research Center, Rua José Rocha Junqueira, 13 Ponte Preta, Campinas, SP, 13045-755, Brazil.
Faculdade São Leopoldo Mandic · BRUniversidade de São Paulo · BRUniversidade Federal de Minas Gerais · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

There is mounting evidence on the importance of some biological processes in tumor growth, such as vascular supply, apoptosis, autophagy, and senescence. We have investigated these processes in polymorphous low-grade adenocarcinoma (PLGA), in an attempt to identify those that are relevant for this particular lesion. We analyzed 31 cases of PLGA using immunohistochemistry to antibodies against CD34 and CD105 to detect blood vessels; against D2-40 to detect lymphatic vessels; against Bax, Bcl-2, and survivin to explore cell apoptosis; and against Beclin and LCB3 to investigate autophagy and against p21 and p16 to assess senescence. Our results showed that PLGA growth does not depend on newly formed vessels but only on preexisting vasculature. Furthermore, PLGA is promoted by autophagy, sustained by both anti-apoptotic and anti-senescence signals, and stimulated by Bcl-2 and survivin.

Indexed as

AdenocarcinomaAdultAgedAged, 80 and overApoptosisAutophagyBiomarkers, TumorCell ProliferationCellular SenescenceFemaleHumansImmunohistochemistryMaleMiddle AgedMouth NeoplasmsNeovascularization, PathologicBiomarkers, TumorAngiogenesisApoptosisAutophagyBcl2LC3BPolymorphous low-grade adenocarcinomaSenescenceSurvivin

Identifiers

PMID28188441
OpenAlexW2586370676

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.