ArticlePediatric nephrology (Berlin, Germany)2017
Clinical utility of spot urine protein-to-creatinine ratio modified by estimated daily creatinine excretion in children.
Article in Pediatric nephrology (Berlin, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed, 13 citations in OpenAlex.
- Comparison of three spot proteinuria measurements for pediatric nephrotic syndrome: based on the International pediatric Nephrology Association 2022 Guidelines.Renal failure · 2023Article
- Diagnostic efficacy and influence factors of urinary protein/creatinine ratio replacing 24-h urine protein as an evaluator of proteinuria in children.International urology and nephrology · 2022Article
- Correlation of urine protein/creatinine ratios to 24-h urinary protein for quantitating proteinuria in children.Pediatric nephrology (Berlin, Germany) · 2020Article
- Educational review: role of the pediatric nephrologists in the work-up and management of kidney stones.Pediatric nephrology (Berlin, Germany) · 2020Review
- Correlation between spot and 24h proteinuria: Derivation and validation of equation to estimate daily proteinuria.PloS one · 2019Article
- Spot urine protein to creatinine ratio.Pediatric nephrology (Berlin, Germany) · 2017Article
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe spot urine protein-to-creatinine ratio (UPCR) is widely used to predict 24-h urine protein (24-h UP) excretion. In patients with low daily urine creatinine excretion (UCr), however, the UPCR may overestimate 24-h UP. The aim of this study was to predict 24-h UP using UPCR adjusted by estimated 24-h UCr in children.
methodsThis study included 442 children whose 24-h UP and spot UPCR were measured concomitantly. Estimated 24-h UCr was calculated using three previously existing equations. We estimated the 24-h UP excretion from UPCR by multiplying the estimated UCr. The results were compared with the measured 24-h UP.
resultsThere was a strong correlation between UPCR and 24-h UP (r = 0.801, P < 0.001), and the correlation improved after multiplying the UPCR by the measured UCr (r = 0.847, P < 0.001). Using the estimated UCr rather than the measured UCr, there was high accuracy and strong correlation between the estimated UPCR weighted by the Cockcroft-Gault equation and 24-h UP. Improvement was also observed in the subgroup (proteinuria vs. non-proteinuria) analysis, particularly in the proteinuria group.
conclusionsThe spot UPCR multiplied by the estimated UCr improved the accuracy of prediction of the 24-h UP in children.
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